Bristol-Myers Squibb Company

Senior Research Investigator--Oncology Mechanistic Disease Discovery (2)

Redwood City, CA, US
Sep 28, 2018
Required Education
Position Type
Full time
We are seeking an experienced scientist to join our Mechanistic Disease Discovery Research team within the Oncology Discovery organization at Bristol-Myers Squibb in Redwood City, CA. This scientist will lead a team responsible for delivering potential biomarker and mechanism of action strategies and data for therapeutic targets in Oncology.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to deliver decisional data for targeted therapies and biomarker identification in oncology. The candidate will lead a team of scientists and effectively collaborate with colleagues in the oncology, discovery chemistry, protein engineering, translational medicine, biomarker, and clinical groups. The successful candidate has superb verbal and written communication skills and is capable of presenting scientific results to multidisciplinary teams, senior management and at external scientific meetings. The candidate will have the opportunity to develop external partnerships/collaborations to advance internal programs, generating data to impact clinical development. This individual will be responsible for interfacing with project leaders and will contribute to patient selection strategies, tumor indication selection strategies, validating targets in primary human tumor samples, and contribute to target engagement and mechanism of action biology to justify development of targeted therapy candidates in oncology.


A Ph.D. degree with 4+ years post-doctoral/Industry experience in cancer biology and genetics or a closely related field is required. Familiarity with biomarker and companion diagnostic identification and their application to clinical samples is required. Deep understanding of bioinformatic application to biomarker analysis, target identification and target validation is critical. Demonstrated ability to design in vitro and in vivo systems to conduct analyses of primary human tissue and cell lines is needed and application of these abilities to targeted therapies is critical. Key technical skills include proficiency in molecular biology techniques and genomics, technical expertise in NGS, cellular pharmacodynamic assay design, biomarker discovery, and interpretation of pharmacology experiments (PK, PD and efficacy). Demonstrated expertise to independently apply bioinformatics and data mining through multi-variate analysis and ability to effectively interact with core bioinformatics colleagues, as well as to use desktop tools/interfaces (e.g., Oncoland, Wuxi) and public databases (CBIO, Achilles, etc.) is required. Excellent interpersonal skills with the ability to interact effectively both internally and externally is required. Experience with multidisciplinary projects and teams with ability to integrate cross-functional information is needed. Management/supervisory experience is necessary. Passion for developing talent and building a highly collaborative and interactive team is essential. Superb oral and written communication skills are required. Ability to effectively present scientific data and concepts across various forums is required. This position is located in Redwood City, CA. There will be less than 10% travel.