Senior Manager, Clinical Informatics

Tarrytown, New York, US
Sep 28, 2018
Required Education
Masters Degree/MBA
Position Type
Full time
The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development.

The position will be responsible for conducting analyses involving clinical and phenotypic data for genetics studies as well as clinical development and commercial programs. Responsibilities will include curating, cleaning, and analyzing large-scale phenotypic datasets, including de-identified EHR extracts from external collaborators, targeted clinical datasets in selected cohorts, and internal datasets from clinical trials and other human subject research. In the future this position may involve managing a team of analysts who will be working with a team of database administrators, biostatisticians, clinical scientists, and programmers to structure and mine clinical and phenotypic data sets and support genomic studies and association analyses. The position will require coordination and collaboration with other scientists within the department, research and clinical scientists at Regeneron, and external collaborators. The position will report to the Head of Clinical Informatics

- Conduct data analysis, including mining and curating of phenotypic datasets with primary responsibility in developing and identifying clinical phenotypes and cohorts of interest for "phenotype first" genomic analysis of associated samples and efficient data mining and association analysis in both phenotype first and genotype first queries.
- Close collaboration and coordination with external health system collaborators and informatics teams mining EHR and phenotypic data sets. Work with these collaborators to structure data and develop algorithms, rules engines, and querying tools to access and curate the phenotypic datasets.
- Manage relationships and projects involving diverse stakeholders. Ensure that analyses are executed in a timely, accurate and reliable manner. Communicate findings clearly to diverse stakeholders and document work for training and replication purposes.
-thought leadership - conferences - bringing ideas back
- Function as a "super user" of either priority Analytic Methodologies or Data Reporting/Management tools.
- Represent the RGC at external meetings; provide scientific and strategic input to the group

This position requires a Master's degree or PhD in Statistics, Computer Science, Information Science, or other relevant analytical/data field, and a minimum of eight years of reporting and/or data analysis experience. Healthcare and EHR data analytics experience are also required. Managerial experience is preferred. Additional requirements include:
- Familiarity with data mining, clinical databases, hospital health informatics databases including Epic or other EHR data structures.
- Familiarity with clinical data standards such as ICD, SNOMED, LOINC, and OMOP, database architecture and administration, as well as SQL programming.
- Experience with HIPAA and experience with IRB protocols around use of use of EHR data.
- Experience working with investigators.
- Involvement in relevant programs such as PCORnet, eMERGE, HMO Research Network, or other such projects is preferred.
- Demonstrates proficiency with quantitative Analytic Methodologies and Data Reporting/Management Tools.
- Demonstrates competence in Data Reporting/Management Tools (e.g. SQL Query Analyzer, Crystal Enterprise).
- Demonstrates understanding of relational database concepts and query tools.
- Demonstrates strong analytical skills
- Demonstrates the ability to multitask and manage simultaneous projects to meet deadlines with a strong attention to detail.
- Demonstrates ability to interpret and communicate analytical information in a clear, concise manner.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.