Senior Scientist I Biomarkers/Translational Medicine, Department of Drug Metabolism Pharmacokinetics

Redwood City, CA, US
Sep 27, 2018
Required Education
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica®, Venclexta™, and Empliciti™ - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie Biotherapeutics (ABR), AbbVie's Center of Innovation in Oncology Research and Development, located in Redwood City, CA. ABR R&D efforts focus on two key areas:

  • Immuno-Oncology (I-O): developing therapeutics that activate the immune system to recognize and eliminate cancer cells
  • Antibody drug conjugates (ADCs); antibodies conjugated to potent toxins for directed delivery to cancerous cells while sparing healthy tissues.
    ABR employs approximately 160 individuals in the San Francisco Bay Area. Its size and entrepreneurial work force allows for effective cross-functional collaboration, agility, and rapid decision making.


The DMPK-BA Department within AbbVie Biotherapeutics in Redwood City is seeking a highly motivated and experienced scientist to responsible for the development and implementation of biomarker and pharmacodynamic assay strategies to enable and support the discovery, development and commercialization of novel therapies. Biomarker/pharmacodyamic assays developed by the scientist and implemented into pre-clinical and early clinical trials would directly inform decision making with regard to dose, dose regimen selection and internal decision making.

Key Responsibilities Includes:
  • Work as part of a highly collaborative interdisciplinary team in an integrated research laboratory.
  • Conduct laboratory studies in support of biomarker/diagnostic strategy development and execution of individual IO research and development projects.
  • Design, implement and monitor biomarker and diagnostic testing as well as data collection in early pre-clinical and clinical trials.

  • Doctoral degree in Pharmacology, Genetics, Immunology, Cancer Biology or Molecular Biology would be desirable.
  • Recent PhD graduates with 0-3 years postdoctoral experience are encouraged to apply.
  • Demonstrated expertise in immunology research.
  • Proficiency in a wide range of immunological laboratory techniques, in particular flow cytometric analysis (FACS).
  • Knowledge/expertise in bioinformatics tools would be highly desireable
  • Ability to communicate scientific concepts and strategies effectively in a science setting.
  • Excellent verbal and written communication and interpersonal skills to work across functions and across sites, and within academic and biotech collaborations.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled