Senior Scientist/Investigator, Computational Chemistry

92121, San Diego
Sep 25, 2018
Required Education
Position Type
Full time

Vividion Therapeutics is seeking an experienced senior computational chemist. Vividion is a privately held biotechnology company based in San Diego that is leveraging an innovative and proprietary chemical proteomics platform that is built on the pioneering work of Prof. Ben Cravatt and co-workers at TSRI.  This platform can interrogate the proteome for binding sites on any protein of interest while simultaneously delivering novel chemical matter.  With this platform, the company has already identified multiple protein targets of high value and potential leads in both oncology and immunology. As an early stage startup company, Vividion is looking for energetic and experienced candidates with a desire to work in a fast-paced and dynamic team environment.

As the founding member of the computational chemistry department, the successful candidate will be responsible for working closely with senior scientists in the internal medicinal chemistry group and the internal structural biology group to design new compounds via computational methods guided by co-crystal structure and advance lead optimization programs targeting these high value proteins.  Other expectations include physiochemical properties analyses, model construction for proteins of unknown structure, SAR analyses and library design to facilitate platform enhancements.  The preferred candidate will have experience with the Schrodinger suite of tools including FEP and Live Design.

Minimum education and experience requirements include:

  • PhD with 5+ years of computational chemistry experience in biotech or pharma
  • Track record of success in advancing programs to clinical candidate nomination
  • Highly organized and able to work in a fast-paced team environment
  • Ability to multitask and adapt to changing priorities including devoting time and energy to building up internal infrastructure as needed
  • Strong written and verbal communication skills

In addition to a competitive compensation package with stock options, Vividion also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability insurance. For consideration, please submit your resume and cover letter referencing job SSCC2018.09.25 to  Vividion Therapeutics, Inc. is an EEO employer.