Scientific Director, Human Genetics

Employer
AbbVie
Location
Lake County, IL, US
Posted
Sep 24, 2018
Ref
1804831
Discipline
Science/R&D, Genetics
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Genomics Research Center (GRC) is a newly created center of excellence for genetics and genomics that supports both Discovery and Development. The GRC plays an integral role towards our goal of developing world class genetics and genomics programs, focusing on finding the right targets and helping us better understand not only human disease biology but also the behavior of and response to our drugs in clinical trials. Two of the pillars of the GRC, the Department of Human Genetics and Pharmacogenomics are responsible for analyzing and interpreting data from large genetic sequencing databases to identify and characterize novel targets for the treatment of diseases across multiple therapeutic areas. We have an exciting opportunity for a Senior Scientist with medical expertise, based in North Chicago, IL reporting to the Head of Human Genetics and Clinical Genetics.

Key Responsibilities:

  • Provide expertise and coordinate clinical activities for human genetic databases. Represent the GRC on various clinical teams involved in defining and harmonizing clinical phenotype information captured in external databases.
  • Provide medical expertise for genetic, genomic or epigenetic studies applied to AbbVie clinical trials.
  • Collaborate with Medical Directors in Clinical Development to identify relevant questions and design studies related to drug response or disease etiology.
  • Collaborate with scientists across different Early Discovery therapeutic areas to interpret and incorporate genetic findings into new targets or for validation of existing targets
  • Provide support for external collaborations and consortia involving human cohorts


The level is commensurate with experience.

Basic:

  • PharmD/PhD or other advanced degree required
  • Relevant experience in genomics, molecular biology, positional cloning, and Genomic Medicine (rare disease genetics and physiological genomics, systems biology, of common complex disease).
  • Minimal clinical trial or medical affairs experience in the pharmaceutical industry or academia or equivalent. 1-2 years of experience is preferred.
  • Deep knowledge of translating genomic data into clinically relevant results.
  • Experience interpreting rare disease clinical data.
  • Experience with large-scale research projects involving next generation DNA sequencing data (e.g. whole exome and whole genome) in conjunction with results from informatics and wide array of molecular biology strategies.
  • Experience or strong knowledge of pharmacogenomics or pharmacogenetics.
  • Demonstrated effective written and verbal communication skills


Preferred:

  • A medical degree, with a strong background in genetic association studies, and family based genetic studies, knowledge of how drugs are developed.
  • The Candidate should have demonstrated ability to design and lead human genetics studies delivering novel genetic findings and medically relevant gene discoveries.
  • Experience working with large human genetic sequencing databases
  • Experience interpreting family-based and rare disease genetic studies
  • Experience with large-scale research projects involving next generation DNA sequencing data (e.g. whole exome and whole genome) as well as array based genotype data
  • Experience or strong knowledge of pharmacogenomics or pharmacogenetics
  • Strong oral and written communication skills in a collaborative environment


Key Leadership Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.


Equal Opportunity Employer Minorities/Women/Veterans/Disabled