Bristol-Myers Squibb Company

Associate Research Scientist

Princeton, NJ, US
Sep 17, 2018
Required Education
Masters Degree/MBA
Position Type
Full time
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

  • Conduct biochemical and biophysical characterization of protein reagents, to analyze purity, integrity, binding activity, and solution phase behavior using gel electrophoresis, Westerns or related methods, LC/MS, light scattering and related techniques
  • Characterize protein structure, stability, and aggregation state, using technologies such as microcalorimetry, spectroscopy, light scattering, analytical ultracentrifugation, etc.
  • Develop and run SPR and other biosensor-based binding assays for characterization of protein/ligand and protein/protein interactions
  • Demonstrate solution binding of proteins with small molecule ligands, and determine binding affinity and stoichiometry, using microcalorimetry and related methods
  • Communicate results written and verbally to supervisor and group team members
  • Maintain a complete and current Electronic Laboratory Notebook
  • Participate on multidisciplinary project teams
  • Plan and carry out experimental studies, analyze and interpret data, and communicate conclusions with teams
  • Present own work within and outside the group

B.S. with 3-5 years or M.S. with 1-3 years relevant experience in Biochemistry, Biophysics, Analytical Chemistry or related field, preferably including experience in a Biotech, Pharma or Biopharma setting.
  • Experience with quantitative analysis of protein-protein interactions using BIAcore surface plasmon resonance (SPR) or related biosensor techniques, including kinetics and affinity, microcalorimetry or related methods, and light scattering is necessary.
  • Experience with protein analytical characterization techniques such as SDS-PAGE, analytical size exclusion chromatography (SEC), liquid chromatography mass spectrometry (LC-MS), is preferred.
  • Experience with biophysical characterization of proteins such as oligomeric structure and stability using microcalorimetry, fluorescence or other spectroscopy, light scattering or other related technologies would also be an advantage.
  • Experience with recombinant protein purification experience including method development, optimization and troubleshooting would be an advantage.
  • Excellent communication skills, evidence of innovative thinking, and ability/potential to function at a high level in a matrixed environment is expected.
  • Additional skills/experience that would be advantageous: familiarity with automation, electronic lab notebook or LIMS systems, protein structure.