Senior Scientist II/III, Pharmacology

South San Francisco, CA, US
Sep 16, 2018
Required Education
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at Stemcentrx, AbbVie's South San Francisco, CA location.


The Research Pharmacology Department is searching for a Senior Scientist II/III who will work collaboratively across DMPK, project-based teams, and biological discovery teams to formulate the in vivo efficacy strategy for various oncology programs, involving antibody drug conjugate and immunotherapy approaches. The candidate will be expected to develop strategies that combine their scientific expertise with in vivo oncology models with operations and resource utilization for projects at various stages. Additionally, the candidate will be responsible to create scientific questions, and coordinate efficacy analyses for communication to other teams via presentations and/or reports. The ability to work independently and efficiently on multiple responsibilities, and effectively participate and communicate as part of team, is a prerequisite.

Key Responsibilities:

  • Lead oncology mouse model establishment and coordination for efficacy and imaging studies
  • Prepare and/or coordinate with team members to review and present/report analyses of efficacy studies for various projects across entire pipeline
  • Contribute Pharmacology knowledge (including pharmacokinetics, pharmacodynamics) and strategy within project team structure
  • Work across discovery teams to integrate efficient workflows for cross-functional analyses and endpoints (for example, biomarkers)
  • Challenge the status-quo and contribute improvements to existing Pharmacology workflows, data visualization tools, efficacy operations, and strategies

Job Requirements:
  • PhD in Molecular & Cell Biology, or a related discipline, with 3+ years of relevant research experience, preferably in a Pharmaceutical or Biotechnology industry setting
  • Hands-on experience with strategy development and detailed design including benchmarks of in vivo efficacy studies
  • Extensive knowledge of oncology models, including patient-derived and cell line-derived xenograft models, and genetically engineered mouse models
  • Experience with pharmacodynamics endpoints, such as biomarkers or in vivo imaging, is a plus
  • Strong written and verbal communication skills
  • Scientific leadership abilities and collaborative personality

Character Requirements:
  • Flexibility and motivation to learn techniques and accomplish goals outside those stated above
  • Ability to manage multiple responsibilities and meet deadlines in a fast-paced environment
  • Entrepreneurial personality, with problem solving skills, critical thinking ability, and excellent communication skills
  • Highly motivated and independent with an ability to adapt to changing priorities in a fast-paced environment
  • Raises the bar and is never satisfied with the status quo
  • Excited to participate in and contribute to company culture