Senior Associate Scientist, Mass Spectometry

Employer
Celgene
Location
San Diego, CA, US
Posted
Sep 15, 2018
Ref
1803132
Required Education
Masters Degree/MBA
Position Type
Full time
Other Locations:US- CA- San Diego

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

The Protein Homeostasis Thematic Center of Excellence (PH TCoE) is seeking an experienced mass spectrometrist for a position within an exciting multi-disciplinary target discovery and proteomics team. The successful candidate will have demonstrable expertise in the operation and maintenance of liquid chromatography-mass spectrometry (LC-MS) systems, and in proteomics sample preparation. The candidate will work collaboratively in a multi-disciplinary environment to deliver field-leading proteomics research in support of small molecule drug discovery and early development projects. Our ideal candidate will exhibit strong technical capabilities, adaptability, a great communicative attitude, and enthusiasm for working towards innovative therapies for patients with cancer, immune-inflammatory, and other unmet medical needs.

Protein Homeostasis at Celgene

The PH TCoE at Celgene is a fundamental research and early development engine that is agnostic to therapeutic modality or disease area. The group integrates discovery research through translational and early clinical development, and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system (UPS), protein translation, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company's most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.

Responsibilities will include but are not limited to, the following:
  • Operation and routine maintenance of LC-MS systems for proteomics research.
  • Monitoring and optimization of LC-MS system performance.
  • Proteomics sample preparation, including tissue culture.
  • Assist in the design of proteomics experiments to meet the needs of PH TCoE projects.
  • Data organization, processing and dissemination.
  • Preparing technical reports and protocols.
  • Reviewing literature, and evaluating/applying relevant novel methods.

    Requirements:
  • Master's degree in analytical chemistry, chemistry, biochemistry or a related discipline, with at least 4 years of work experience operating and maintaining LC-MS systems, or Bachelor's degree with at least 6 years of work experience.
  • Deep understanding of proteomics mass spectrometry, and protein and peptide chemistry is essential.
  • Hands-on experience with nanoflow LC systems and hybrid mass spectrometers (Orbitrap is preferred)
  • Experience with LC-MS method development.
  • Proficiency with proteomics data processing workflows. Familiarity with data handling languages and tools (e.g. Python, R, Knime, Vortex etc.) and LIMS is an advantage.
  • Practical experience with protein chemistry, molecular biology and/or tissue culture.
  • Excellent organizational and communication skills, with a commitment to delivering high quality research.


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BIO-US

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.