Principal Scientist - CAR-T Development Lead

91361, Thousand Oaks
Sep 14, 2018
Required Education
Position Type
Full time


Position Summary The Principal Scientist-CAR-T Platform Development Leadis an integral member of the Preclinical Sciences Laboratory Group and brings extensive engineered T cell product development expertise. This principal role oversees the allogeneic, off-the-shelf CAR-T development laboratory team tasked with developing new product candidates for our expanding pipeline. The candidate must have an established record of leadership in an academic or industry setting with extensive laboratory-based CAR-T cell expertise.

Reports to                Sr. Director of Preclinical & Translational Science

Location                   Thousand Oaks (northwest Los Angeles area), CA  

Position Responsibilities

Applies expert knowledge in the field of CAR-T Therapy to lead laboratory team designing and generating new CAR-T product candidates using Atara Bio’s novel allogeneic engineered T cell therapeutics platform. Coordinates multiple programs to validate targets, optimize CAR construct design and CAR-T cell generation, and explore therapeutic potential of resulting CAR-T lead candidates. Mentors a group of diverse scientists and research associates to facilitate new CAR-T programs and oversee IND-enabling in vitro. Independently designs and executes studies to facilitate preclinical proof-of-concept activity for efficacy and safety. Coordinates reports, summaries, and presentations supporting experimental results. Oversees continued growth and recruitment activities to expand CAR-T laboratory research group. Develops and leads strong collaborative relationships with internal and external groups. Manages activity of direct reports and preclinical development project teams. Role model for Atara’s Values of patients first, innovation teamwork, community and mindset.

Travel   Travel may be required (up to 10%). Physical Requirements:

Subject to extended periods of sitting and/or standing, vision to monitor and moderate noise levels. Work is generally performed in an office, laboratory, or manufacturing environment. Car and airplane (see above) travel is an essential part of the job  

Position Requirements

Ph.D. with at least 8 years of experience in a Cellular/Molecular Immunology and immuno-oncology field, with industry experience required. Expertise and broad functional, laboratory-based CAR-T and/or T cell engineering expertise. Must possess extensive working knowledge of CAR-T design, T-cell biology, immunotherapies, retroviral, and gene-editing technologies, including CRISPR/CAS9 system. Expertise with current landscape of engineered T cell platforms and approaches to modulate the tumor/immune microenvironment. Record of productivity and innovation in the engineered T cell space as evidenced by publications and/or patents. Proficient with flow cytometry-based applications. Ability to Independently propose, design, execute, and report research projects. Experience leading a small group of scientists capable of handling tight timelines and delivery of quality data. Evidence of independent thinking and leadership skills are vital.