Pharmacyclics, LLC

Senior Scientist I, Biology

Location
Sunnyvale, CA, United States
Posted
Sep 13, 2018
Ref
2514
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

To learn more about us, please visit us at http://www.pharmacyclics.com/

Pharmacyclics is seeking a Senior Scientist I, Drug Discovery.

General Position Summary/Purposes

Provide strong scientific and technical initiative and hands-on implementation of assay development and new target identification/validation in the fields of hematologic malignancies and immuno-oncology. Conceive and execute novel scientific approaches to achieve departmental project goals.

Key Accountabilities/Core Job Responsibilities

  • Demonstrate scientific independence & leadership to establish and implement strategies for understanding the mechanisms of action of drugs and translation into future therapies for new indications in hematological malignancies.
  • Devise and implement strategies to identify new targets in hematological malignancies and immune-oncology.
  • Design hypothesis-driven proposals and studies to inform structure-activity relationships or mechanisms of action of drugs or drug candidates in hematologic cancer such as CLL or non-Hodgkin lymphoma.
  • Lead hypothesis-generating pre-clinical studies that inform mechanisms of resistance and/or rationales for therapeutic combinations.
  • Hands-on execution: Advance science from the bench, design and execute in vitro or ex vivo experiments to determine potency and selectivity of drug development compounds using cell lines and primary human cell sources. Lead the development, optimization, and validation of new assays.
  • Apply cell and molecular biology techniques to identify and evaluate cellular efficacy and selectivity endpoints. Utilize technical expertise and available information to troubleshoot and resolve key project hurdles when encountered.
  • Actively participate in internal and external scientific meetings by presenting and critically evaluating emerging scientific literature to contribute to projects.
  • Perform and manage in-house, CRO, or collaborative research to support the development of therapies in a variety of hematological malignancies.
  • Prioritize tasks and contribute to a highly motivated and productive research team with a sense of urgency and desire to meet project timelines.
  • Impact projects through experimental designs, critical analysis and interpretation of results and communication of results promptly.
  • Strong relationships with peers and cross functionally with partners to achieve high performance. Strongly embrace the ideas of others and nurtures innovations.

Qualifications:

  • Bachelor's Degree or equivalent education and typically 10 years of experience, Master's Degree or equivalent education and ty pically 8 years of experience, PhD and no experience necessary.
  • Ph.D with postdoctoral training in immunology/cancer biology or related fields is heavily preferred.
  • Strong track record of peer-reviewed publications and presentations.
  • Drug development expertise in the oncology field is preferred.
  • Strong interpersonal skills to thrive in a team environment.
  • Effective written and verbal communication skills.

Required Experience:

  • Expertise in cancer biology skill sets including gain of function or loss of function techniques to validate targets.
  • Expertise in ELISA, western blotting, cell culture, separation techniques for primary cells, cell-based assays, and gene expression analysis.
  • Strongly prefer candidates with hands on experience with flow cytometry.
  • Experience with techniques to transduce suspended cells is also preferred.
  • Experience with cell-based and/or biochemical assay development, optimization and troubleshooting.
  • Experience in using cell biology models to validate compound potency and elucidate molecular mechanisms of action.
  • Working experience with antibody development is preferred.
  • Broadly trained in immunology/cancer biology, as indicated by peer reviewed publication in top tier journals and presentations at national or international conferences. Working knowledge of lymphocyte biology, cell subsets, and lineage markers.
  • Willing to troubleshoot experimental procedures and should be adaptable to changing requirements of the project.
  • Experience in biological data analysis tools (GraphPad Prism, FACS DIVA, FlowJo, etc).


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