The Laboratory for Experimental Medicine (LEM) Mass Spec / Antibody Engineering group collaborates with the Immunosafety Team within ToxPath and Lilly Biotechnology, San Diego to develop a comprehensive dendritic cell-based platform to evaluate the risk of immunogenicity. MHC-associated peptide proteomics (MAPPs) has proven to be an indispensable capability that identifies those regions of biologic molecules that are displayed by antigen presenting cells (APCs) for T cell activation. The generation of APCs is a fundamental requirement for MAPPs and enables 1) the identification of the precise sequences that lead to T cell response, 2) the engineering of biologics with lower risk of immunogenicity and 3) a refinement of in silico immunogenicity prediction tools.
Are you looking for an exciting career in drug discovery? We are looking for an energetic scientist to join our dynamic team. Some of your responsibilities in this role are:
- generation of monocyte-derived dendritic cells,
- isolation of DNA from dendritic cells for HLA typing,
- assisting with MAPPs technology/process improvements and
- assisting with T cell proliferation assays for the analysis of peptides identified by MAPPs.
Other key opportunities are:
- Research related to immunogenicity – working in team-oriented and multidisciplinary environment the scientist will aid in the investigation of the drivers of immunogenicity. Scientist will be responsible for all aspects of the generation of antigen presenting cells. Scientist will also be responsible for generation of genomic DNA for HLA-typing.
- Communication and information management – scientist will play key role in accurate record keeping of raw data and communication of results to immunosafety team colleagues and clinical teams.
- Technical writing skills – scientist will maintain all experiments and results in E-notebook. Consultant will also be responsible for appropriate section writing/editing of any necessary documents.
- Technical process application and improvement – scientist will develop and maintain expertise to conduct in vitro experiments addressing drug immunogenicity.
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
- BS degree in Immunology, Molecular/Cell biology or related discipline with at least 1 year of experience or
- MS in Immunology, Molecular/Cell biology or related discipline with relevant research experience
- Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
- Demonstrated cell culture experience with both cell lines and primary cells.
- Demonstrated experience with various molecular biology techniques.
- Expertise with various computer software programs for the analysis and presentation of data and results.
- Experimental design; scientific approach to problem solving; method development, optimization and validation.
- Ability to influence change and implement process improvement.