Scientist - Transporters
Amgen is seeking a Scientist to join the Pharmacokinetics and Drug Metabolism (PKDM) department at our Kendall Square site in Cambridge, Massachusetts.
In this role you will contribute to the discovery and non-clinical development of small molecule therapeutics across several disease areas, with a primary focus on drug transporters including novel transport mechanisms as it relates to absorption, distribution, metabolism and elimination (ADME). You will be responsible for conducting/optimizing in vitro studies, investigating the suitability of in newer technologies to evaluate the role of drug transporters in drug disposition and improve our predictions for tissue exposure assessment and drug-drug interactions (DDIs). You will have the opportunity to design, initiate in vivo studies and interpret the results to improve mechanistic and translational understanding as it relates to pharmacokinetics, pharmacodynamics and toxicokinetics of new chemical matter. In addition, you will have the opportunity to learn about a wide variety of modalities including, but not limited to, protein therapeutics.
In this position, your core responsibilities are to:
- Serve as a functional representative and subject matter expert on the transporter science as it pertains to drug disposition, collaborating with scientists from various other sub-disciplines and project representatives across our three-site PKDM scientific community (Cambridge, MA, San Francisco and Thousand Oaks, CA).
- Evaluate and implement emerging in vitro and in silico tools to support the prediction of transporter-mediated pharmacokinetics (PK) and drug interactions (DDIs) in humans
- Articulate risk and mitigation strategies for human PK and DDI predictions
- Design and complete IND and NDA-enabling studies and reports to support regulatory submissions
In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the fundamental physiological and biochemical factors that determine the absorption, distribution, and clearance of small molecule and protein therapeutics. A collaborative and highly capable scientific community at Amgen is available to support these efforts. Interactions and collaboration with academic and other external scientists is highly encouraged.
Master's degree and 4 years of scientific experience
Bachelor's degree and 6 years of scientific experience
- A Ph.D. in pharmaceutical, chemical, or biological science
- 0-4 years of drug discovery and/or development experience
- Expertise with implementing, optimizing and troubleshooting in vitro transporter assays
- Knowledge of PK and distribution of small molecule therapeutics is desirable
- Knowledge of physiologically based pharmacokinetic modeling is a plus.
- Critical thinking and demonstrated ability to communicate with team members across broad disciplines
- Effective oral and written communication skills
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.