Scientist / Senior Scientist- Protein Engineering

Employer
SystImmune, Inc.
Location
98052, Redmond
Posted
Sep 10, 2018
Required Education
Bachelors Degree
Position Type
Full time

Job Title: Scientist / Senior Scientist                                                       

Department: Protein Engineering

Reports To: Associate Director

FLSA Status: Exempt

 

Summary:

Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.


We are seeking a talented Scientist / Senior Scientist with extensive experience in antibody-based therapeutics, in Protein Engineering Department. The successful candidate will have a tracked record of antibody humanization, engineering, molecular biology, purification and characterization.


Essential Duties and Responsibilities:
• Lead and participate in antibody humanization and engineering for novel therapeutic multi-specific antibodies and Antibody Drug Conjugate (ADC).
• Responsible for cloning, expression and characterization of protein constructs
• Oversee CDR grafting, germlining and humanization
• Experienced with PTM site removal and optimization by structure-guided approach
• Evaluate signal peptides for CHO expression system and familiar with CHO expression vectors
• Responsible for candidate optimization, selection, and validation.
• Hands on in homology modeling, mammalian expression, surface plasmon resonance, flow cytometry, SDS-PAGE are required, HPLC is a plus
• Proficiency with Pymol, IgBlast, Discovery Studio, abYsis, Geneious are required
• Write and review Standard Operating Procedures (SOP)
• Support and closely work with other divisions to advance company goals
• Work with R&D and manufacturing department in China. Plan time to accommodate meetings and technical support with team members in China
• Participate in timeline planning and decision making regarding research priorities of company or department and provide information on feasibility of prospective projects.
• Other duties as assigned.


Qualifications:
To perform this job successfully an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Education & Experience
• PhD; MS; BS in Molecular Biology, Structural Biology, Biochemistry or a related field with 5+ years (PhD); 9+ years (MS); 12+ years (BS) of relevant academic and/or pharmaceutical or biotech experience
• Strong fundamental knowledge and experience in antibody humanization and engineering
• Extensive experience with homology modeling and structure-base mutagenesis