Senior Manager, Automation Infrastructure

Employer
AveXis Inc.
Location
Durham, NC, US
Posted
Sep 07, 2018
Ref
2018-2478
Required Education
Bachelors Degree
Position Type
Full time
Overview

Ready to join a team committed to moving gene therapies into the clinical and commercial settings for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science to treat rare and life-threatening genetic diseases starting with our clinical-stage, proprietary gene therapy candidate, AVXS-101. We are in the midst of an incredible journey, and are looking for passionate individuals to join us on this important mission.

AveXis, Inc., a Novartis Company , is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

AveXis is seeking a Senior Manager, Automation Infrastructure responsible for the manufacturing infrastructure at multiple sites which includes network hardware and configuration, and server hardware and configuration (including virtualization). Experience designing and maintaining GMP automation infrastructure is required.

Responsibilities

  • Manage and support GMP data center and network infrastructures across the North America region.
  • Lead design effort for new data center infrastructure deployment.
  • Update and maintain network infrastructure to reliably support manufacturing systems with a robust security posture.
  • Manage and direct infrastructure lifecycle management for GxP systems.
  • Hire and manage staff to support infrastructure operations at the site level.
  • Support and manage 24x7 site-based and regional operations.
  • Define infrastructure standards and policies where appropriate.
  • Implement and revise SOPs to conform with standards and directives.
  • Manage external vendor contracts to ensure that deliverables and time schedules are met.
  • Deploy, maintain, and upgrade virtual platforms, storage arrays, network components.
  • Architect infrastructure qualification and lifecycle management procedures.
  • Manage GMP domain and user access.


Qualifications

  • 10+ years' experience in IT infrastructure management/industrial network design.
  • Extensive experience in GMP industry.
  • Bachelor's degree in IT or related field.
  • Hands-on experience and in-depth knowledge of industrial networking.
  • Virtualization (VMWare ESX) design, deployment, and management.
  • Winders Server.
  • Managed ethernet switch configuration.
  • IEC 62443 (ISA-S99) IT Infrastructure design.
  • Highly experienced in GAMP5 lifecycle management.
  • Active Directory.
  • Disaster Recovery.
  • Change control.
  • IT Service Management.
  • Network Administration.
  • Must be willing to travel 25%.
  • Ability to lead multiple projects and teams at the same time.
  • Change control experience.


The level of this position will be based on the final candidate's qualifications.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.