Senior Staff Scientist, R&D Chemometrics

Location
Hayward, CA
Posted
Sep 07, 2018
Required Education
Masters Degree/MBA
Position Type
Full time

The Senior Staff Scientist must have prior experience with precision optical instruments and medical devices.  Specialties should include spectroscopy, optic design, multivariate analysis and system engineering.  This person shall serve as the inhouse expert in the manufacturing of the spectrometer, and be directly responsible for translating specifications into meaningful manufacturing and test procedures.  From a practical perspective, this person must have a detailed understanding of the spectra measured by the product.

Essential Duties and Responsibilities include the following. Other duties may be assigned.  

  • Characterize current testing for spectrometer design: Understand how measurement accuracy effects glucose prediction and improve analysis of filter scans in the “AutoTUVI” process. One project stemming from this is the nitrogen purge. Perform appropriate analysis on all problems related to spectrometers and systems, including all No Reads.   
  • Blood Glucose Accuracy Tests (BGA):  Analyze test data and determine system bias.  As required, identify cause of any variation from system to system and propose changes to improve manufacturing process or spectrometer design.
  • Clinical Study Data:  Develop and maintain data structures and data summary including subject specific analysis of all clinical data.  This information is used for algorithm development, interference analysis and system performance troubleshooting. 
    • Interferences:  Identify clinical subjects presenting with interferences. Develop, where possible, interference spectra using clinical data and demonstrate interference correction using these spectra.  
    • Non-interference Errors:  Identify and quantify glucose prediction errors due to sources other than interferences.  These include dilution, flow cell changes and temperature. Develop techniques to identify and if possible, correct these spectra.
    •  
    • Projects: 
  • Start-Up Bias:  Analyze initial scans of disposables to determine if the glucose prediction error is different from the “steady-state” scans. If so, quantify the effect, identify the cause and propose an algorithm solution.
  • Path Length Induced Error:  Quantify errors in glucose prediction caused by rapid path length change in the first few hours of disposable operation.  If necessary, propose algorithm changes that reduce the error
  • Disposable Life Time Tests: Analyze all 72 hour disposable test and quantify path length, and bubble performance.
  • Algorithm Testing: Develop and analyze tests for qualification of new algorithm changes.

Knowledge, Skill and Competency Requirements:

·      At least 10 years experience in computational algorithm development/chemometrics. Development of laboratory equipment and/or medical devices desired.

·      Familiarity with laboratory reference equipment (e.g., YSI, Radiometer, Beckman)

·      Fluency with computing software such as Matlab

·      Excellent communication skills. Ability to communicate verbally and in writing.

·      Excellent team player:  flexible and easy to work with, results oriented. Works well with other engineering.

Education/Experience:

MS, PhD in mathematics, physics or related fields 

Supervisory Responsibilities: 

This job has no supervisory responsibilities.