Research Scientist I: Fibrosis
Job Title: Research Scientist I: Fibrosis
Job Type: Regular, Full-Time
Location: Foster City, CA
We are seeking an exceptional scientist to join the Fibrosis Biology group at Gilead. This individual will have the unique opportunity to drive discovery and translational research efforts aimed at enabling clinical development. This will involve identifying and characterizing novel therapeutic targets for fibrotic diseases, applying sound scientific method to identifying critical path questions, and presentation of results to senior management. The position will require both good communication and managerial skills in order to interface effectively with other functional support groups (histopathology, high-throughput biology, and bioinformatics) and manage activities of highly skilled associate scientists. The successful candidate will also participate in evaluation of external licensing opportunities.
Gilead Sciences is a world leader in antiviral research having developed small molecule compounds that have revolutionized the treatment of HIV, HCV, and HBV. Over the last 5 years, Gilead has significantly broadened its scope to encompass unmet medical needs in inflammatory and chronic fibrotic diseases including non-alcoholic steatohepatitis (NASH) and diabetic kidney disease (DKD). Gilead has developed a pipeline of investigational compounds which are currently in late-stage clinical trials for NASH. Our research team is intensely engaged in the discovery and development of additional small molecule and antibody therapeutics and combination therapies for patients with advanced liver fibrosis. This position provides an exciting opportunity to have high-impact participation in the growth of these new therapeutic areas within an established, well-funded, research group focused on developing drugs for fibrotic diseases.
Essential Duties and Job Responsibilities:
The successful candidate will work in a project team-based research structure to lead or support biological investigation of new and established targets within Research. The candidate will be expected to identify key questions and design hypothesis-based experiments that support established programs moving into development, as well as identify and/or evaluate new targets in fibrotic diseases that complement our current portfolio. The candidate will be expected to lead biology efforts, manage associate scientists, and work within a team composed of a broad range of functional groups (eg. medicinal chemistry, drug metabolism, formulations, high-throughput biology) to effectively develop new drugs. The candidate will also oversee and/or directly manage new and established external collaborations. The successful candidate will participate as an engaged member of the highly interactive Biology department. Knowledge, Experience and Skills: Applicants must have a PhD or equivalent degree and at least 3+ years of relevant post-graduate experience. Employment in the pharmaceutical industry is a plus. The candidate should be fluent in the use of molecular techniques to evaluate signaling networks (eg. western blotting, ELISA, proteomics, gene expression analysis, siRNA/shRNA) and have experience developing in vitro and/or in vivo models.
Preference will be given to a candidate who is pro-active, a good team-player, and has a history of independently designing experiments that answer specific scientific hypotheses or questions. Candidates with an understanding of molecular pathways that contribute to fibrosis, and who have direct experience in hepatocyte, activated fibroblast, and/or immune cell signaling assay development are encouraged to apply. A working knowledge of the design and execution of in vivo pharmacology studies with relevant preclinical models is a plus.
This individual will have demonstrable experience in hypothesis-driven biological research. Strong communication skills are required, with an ability to communicate and scientifically engage individuals across a large breadth of levels and translate ideas and data into concise written and verbal communications.