Staff Scientist, Protein Therapeutics

Location
San Francisco, CA, United States
Posted
Sep 06, 2018
Ref
3134-187-R
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
Position Overview

Nektar has an exciting opportunity available for a senior level Staff Scientist in our Protein Therapeutics group located in our San Francisco office (Mission Bay area).

This individual will oversee the protein conjugation group to initiate and direct the development of proprietary polymer-protein or polymer-peptide conjugates, including screening conjugations, and the purification and analytical characterization of those conjugates. S/he leads in the planning and execution of scientific experimentation to support the protein therapeutic pipeline for the company; applies knowledge of protein chemistry to design and develop appropriate data sets that support company initiatives; plans and conducts workflows for scale-up protein conjugate purification; develops conjugation and purification processes and develops analytical methods for Research and to support tech transfer for manufacturing; and manages workflow among a complex set of projects, collaborators, personnel, and sites. This position contributes to and supports the company's research and development efforts to create high value therapeutics to address unmet medical needs.

The successful candidate will: • Work on a wide range of extremely complex problems where causal relationships are difficult to establish, analysis requires evaluation of intangible variables and the use of creative thinking is required. Reports data, interpretations and recommendations. • Work independently as part of a broad program, setting own priorities and schedules. • Apply and interpret theories, concepts and techniques in several disciplines. • Contribute significantly to planning of annual programs and to the completion of these programs. • Work on multiple projects simultaneously, where coordination of efforts among various sites and attention to critical timelines is essential to success. • Critically analyze complex data and interprets experimental results. • Supervise, mentor and train individuals. • Direct protein or peptide conjugation strategies and independently synthesizes and analyzes conjugates to support the protein therapeutic pipeline. • Direct, develop and optimize conditions for chemical conjugation, purification and analysis of polymer-protein or polymer-peptide conjugates. • Work directly with biology and pharmacology teams to characterize the in vivo and in vitro activity of various polymer-polypeptide conjugates. • Interface, work with and support various departments at multiple locations. • Plan and coordinate activities with other scientists, team members and the patent department. • Develop analytical methods for characterization, lot release and technology transfer.

• Express proteins in appropriate cell culture hosts in small to medium scale for research, pharmacology, analytical or other purposes. • Identify and coordinate access to additional resources. • Write complex reports and protocols. • Ensure thorough documentation of laboratory activities; technical reports detailing development efforts, analytical development reports, batch records, or technology transfer reports. • Contribute to patent applications and IND filings as needed. • Perform technology transfer to clients or internal Process Development/ Manufacturing. • Orally present information as needed. • Travel to client site or other company functions as needed.

The successful candidate may: • May assist with designing and implementing organizational processes, budgetary and capital equipment requirements. • Work may be reviewed for soundness of technical judgment to determine if desired objectives have been met.

A PhD in Biochemistry, Chemical Engineering, Chemistry or related field is required. Exceptional non-PhDs with demonstrated capabilities or relevant industrial/ biotechnology experience may be considered. A minimum of 10 years work experience in a research and/or development environment is required. Post-doctoral work may serve as experience. Prior supervisory experience highly desired.

Additional Requirements: • Demonstrated knowledge of protein conjugation technologies, production, purification, characterization, HPLC method development, analytical method development and downstream process methodology is expected. • Experience with mass spectrometry and peptide mapping is required. • Must have hands-on experience in protein chemistry and be thoroughly familiar with basic protein chemistry tools such as SDS-PAGE, IEF and western blotting. • Experience with small to medium scale expression of proteins is highly desirable.

• Experience with affinity chromatography, IEX, RP, SEC, or other methods, both for purification and for analytical development, is required. Methods may also be developed for MALDI-MS, LCMS or CE. • Thorough knowledge of HPLC and FPLC (e.g. AKTA) method development is required. • Experience in protein/peptide stability testing or formulations development is highly desirable. • Must be able to clearly communicate scientific information. • Must have good interpersonal skills and be willing to work as part of a team. • Must have the ability to effectively work with all levels of scientists and management, including foreign collaborators. • Excellent scientific writing, communication, presentation, documentation, and computer skills required. • Ability to work internationally and across multiple corporate sites. • Must be a team player who can mentor and work closely with both research and process development. • Must be able to exert influence effectively. • Must be able to demonstrate sound judgment and problem solving capabilities. • Strong organizational skills are required. Experience working in an FDA regulated environment and knowledge of current GMPs as they apply to laboratory practices are highly desired. • Must be able to demonstrate broad success in technical proficiency, scientific creativity, collaboration with others and independent thought. • Must represent the leading edge in field, while able to demonstrate expert knowledge in scientific principles and concepts both internally and externally with sustained performance and significant accomplishment on at least one area. • Must be proficient in common office computer applications.

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.