Cell Culture Development Co-op

Location
Tarrytown, New York, US
Posted
Sep 05, 2018
Ref
14154BR
Required Education
Bachelors Degree
Position Type
Part time

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

These positions are in Cell Culture and Medium Development within Preclinical Manufacturing & Process Development in Tarrytown, NY. There are 5 position for Spring AND Summer (full time, about 7 months from January to August 2019) and 5 positions for Summer AND Fall (full time, about 7 months from May/June to December 2019)

Positions 1 and 2: (Spring/ Summer and Summer/Fall)
The students will assist in the development of processes producing potential therapeutics using mammalian cell culture. The student will use bench scale bioreactors to evaluate cell line candidates based on cell growth, cell productivity, and product quality. Optimally performing cell lines will be transferred and utilized in clinical manufacturing of therapeutic antibodies. Additionally, the student will assist in the development of the platform processes that are used in the initial evaluations of cell line candidates. The student will also assist ongoing efforts to characterize the precision and variability of analytical tools and process equipment.

Position 3: (Spring/Summer)
This student will assist in the development of processes producing potential therapeutics using mammalian cell culture. The student will use bench scale bioreactors as well as automated high throughput bioreactor systems to optimize cell culture processes in order to support late stage clinical trials and commercial manufacturing. Daily responsibilities will include:

• Cell cultivation in shaker flasks and bioreactors (2-5L scale, automated bioreactor system)

• Benchtop bioreactor operation and maintenance

• Use of statistical modeling to analyze and interpret design of experiment data

• Medium and reagent preparation

• Laboratory organization and cleaning
Concepts from coursework in process control, mass transfer, and basic chemistry will be routinely applied to experimental activities. The ability to design experiments, interpret results, and communicate findings will be developed as part of the cooperative education experience.

Position 4: (Summer/Fall)
This student will support the development of late stage cell culture bioreactor processes. Project will be timeline dependent but potentially could include cell line screening and medium development for a post commercial process. This may involve evaluating compatibility of continuous technologies. Daily responsibilities will include:

• Cell cultivation in shaker flasks and bioreactors (2-5L scale)

• Benchtop bioreactor operation and maintenance

• Medium and reagent preparation

• Laboratory organization and cleaning

Positions 5 and 6: (Spring/ Summer and Summer/Fall)
This student will assist in the development of processes producing potential therapeutics using mammalian cell culture. He/she will use sterile technique in executing shake flask and benchtop-scale bioreactor experiments to develop cell culture media formulations that improve cell growth, cell productivity, and product quality. He/she may also evaluate different technologies for their potential use in development programs. Concepts from coursework in cell biology, mass transfer, and basic chemistry will be routinely applied to experimental activities. The ability to design experiments, interpret results, and communicate findings will be developed as part of the cooperative education experience.

Positions 7 and 8: (Spring/ Summer and Summer/Fall)
The student will be exposed to real-world responsibilities, comprehensive basic training and guidance to participate in the development of new media and feed formulations to improve the production of biotherapeutics. The student will support cell culture experiments in shake flasks, ambr and bench scale bioreactors. He/she will assist with Metabolic Flux Analysis (MFA), predictive modeling, statistical data analysis, among other techniques to increase our understanding and improve cell culture process efficiency based on evaluation of historical and real time process and cell metabolism data.

Familiarity with data analysis techniques and modeling is highly desirable. Concepts from coursework in metabolism, mass transfer, programing, kinetics and biotechnology will be applied to experimental and data analysis activities. The ability to design experiments, interpret results, and communicate findings will be developed as part of the cooperative education experience.

Positions 9 and 10: (Spring/ Summer and Summer/Fall)
The student will assist on-going work in Medium Development, within the Cell Culture Development group. Specifically, the project will focus on small-scale, high-throughput screening experiments designed to understand the metabolic profile of our cell lines. Further, the information gained from scale-down experiments will be used to tailor feeding strategies for current and future cell lines to improve productivity and product quality of continuous processes. The student will develop skills in experimental design, medium development, sterile cell culture technique and data analysis.

Start building your skills at Regeneron.

• Must be an undergraduate student (positions 7-8 will consider a MS, too)

• Must be pursuing a degree in Chemical Engineering, Biomedical Engineering, or Bioengineering. May consider Biotechnology, Biology, and related majors.

• Previous lab experience and cell culture experience is preferred

• Programming experience a plus for positions 7-8

General Co-op Program Information:

• Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD

• Program is full-time (40 hrs/wk) and is paid

• Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community

• Minimum GPA of 3.0

• You will work with a specific manager on a project(s)

• Enjoy regular 1 hour Co-op Program events: learn about other areas of the company from employees, soft skills workshops, networking, volunteering, and more!

• Present to your team on your project(s)

Transportation and Housing:

• A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus

• Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.