Scientist, Medicinal Chemistry

98119, Seattle, WA
Sep 04, 2018
Required Education
Position Type
Full time

As a member of our Discovery division, you’ll be supporting research project teams with medicinal chemistry. This will include the design and synthesis of organic molecules to enable drug discovery.

Good things are happening at Omeros!

Come join our Discovery Group!

Who is Omeros?

Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market as well as orphan indications targeting inflammation, complement-mediated diseases and disorders of the central nervous system.

The company’s drug product OMIDRIA® (phenylephrine and ketorolac injection) 1% / 0.3% is marketed in the U.S. for use during cataract surgery or intraocular lens (IOL) replacement to maintain pupil size by preventing intraoperative miosis (pupil constriction) and to reduce postoperative ocular pain. In the European Union, the European Commission has approved OMIDRIA for use in cataract surgery and other IOL replacement procedures to maintain mydriasis (pupil dilation), prevent miosis (pupil constriction), and to reduce postoperative eye pain.


Omeros has multiple Phase 3 and Phase 2 clinical-stage development programs focused on: complement-associated thrombotic microangiopathies; complement-mediated glomerulonephropathies; Huntington’s disease and cognitive impairment; and addictive and compulsive disorders. In addition, Omeros has a diverse group of preclinical programs and a proprietary G protein-coupled receptor (GPCR) platform through which it controls 54 new GPCR drug targets and corresponding compounds, a number of which are in preclinical development. The company also exclusively possesses a novel antibody-generating platform.

What are your job responsibilities?

  • Designing and synthesizing potential drug candidate molecules



  • Conducting complex air-and moisture-sensitive chemical reactions



  • Characterizing organic compounds using routine methods (NMR, HPLC/MS, etc.)



  • Understanding and applying DMPK and biological principals toward the design of small molecules as well as discussing and maintaining structure activity relationships of compounds



  • Analyzing, preparing and presenting scientific results and data effectively as well as managing and archiving data



  • Attending project meetings



  • Effectively use chemical literature and chemistry related software

What experience and education do you need?

You’ll need to have a Ph.D. and either a post-doctoral or 3-5 years of industrial experience in synthetic organic chemistry.

Additionally, we are seeking candidates with the following experience:

  • Industry experience in organic synthesis with the proven ability to design and synthesize novel compounds  
  • Experience with purification methods and characterization of compounds such as NMR and LCMS is required
  • CNS experience is a plus

What skills does our ideal candidate have?

As our ideal candidate, you'll need the following skills and knowledge:

  • Excellent written, verbal and time managements skills, along with a team oriented and highly motivated demeanor
  • Strong analytical and problem-solving skills, attention to detail 
  • The ability to work effectively under pressure and handle multiple priorities simultaneously is essential, as is the ability to build and maintain positive relationships with management, peers and subordinates
  • Demonstrated proficiency in using MS Office applications is also required



If you have the skills, knowledge and experience we are looking for, we’d love to hear from you!


Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to or contact Omeros, asking for Human Resources, at (206) 676-5000.