Eli Lilly and Company

Principal Research Scientist-Pharmaceutical Solid Form

Indianapolis, Indiana
Aug 29, 2018
Science/R&D, Chemistry
Required Education
Masters Degree/MBA
Position Type
Full time


Do you seek an opportunity to lead a team of highly talented scientists engaged in the design and development of solid forms of small molecules and peptides, leveraging state-of-the-art in vitro and in silico tools and techniques, integrating physical form and material properties with product design and performance criteria, while simultaneously driving innovation and responding to business needs? Do you have deep technical knowledge and leadership experience with pharmaceutical solid forms, spanning all the way from discovery to commercialization? Do you have experience in people development, and an internal motivation to achieve quality results in a fast-paced environment? If so, we have a role for you!
Small Molecule Design and Development (SMDD) is comprised of diverse groups that design and execute the development of all CMC aspects of small molecules from pre-clinical phases through commercialization for drug substances and drug products.  With a goal of enabling next generation discovery and development, we seek to develop and explore new and innovative technical solutions across our portfolio. This work will focus on leadership in the design and development of solid forms in a manner that integrates solid forms with drug substance physical properties, product design and performance.

You will leverage strong leadership skills and technical background to:

  • Lead a highly talented and motivated group of individuals  to rapidly assess risks for solid forms and to develop and deliver a solid-state agenda to mitigate those risks
  • Collaborate and communicate project-specific challenges and opportunities with key partners within the company and in the external network, while navigating a complex, matrixed environment and meeting stakeholder expectations.
  • Serve as an effective team leader by addressing the development needs of individual members and maintaining a healthy team environment.
  • Partner with Discovery and groups within Small Molecule Design and Development organization, and develop strong cross-functional relationships to deliver developable and commercializable solid forms of compounds.
  • Drive innovation through internal efforts and external partnerships.
  • Integrate deliverables of the group with the needs of partner functions to ensure business relevance and solid portfolio impact.
  • Build and leverage internal and external networks, and provide leadership to solve complex technical problems and to identify and implement new tools and technologies that enhance internal capabilities and processes such as understanding solid form physical properties and their translation to early and late phase development.
  • Author and review high quality technical reports, peer reviewed publications, and regulatory documentation to support new technologies and/or regulatory submissions.

Company Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Basic Qualifications

  • Ph.D. in organic, inorganic or physical chemistry, material science, or other related disciplines with a minimum of 6 years of experience
  • Demonstrated leadership in pharmaceutical sciences in the area of solid form discovery and development

Additional Information

  • Limited travel may be required
  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.                        

Additional Skills/Preferences

  • Demonstrated expertise with identifying commercially viable forms that have led to marketed products.
  • Deep understanding of solid form screening and selection for commercial development. Ability to guide: a) drug substance crystallization activities, b) computational modeling of physical properties, c) crystal structure predictions and other solid-state modeling and d) material properties design.
  • Knowledge of impact of drug substance physical properties on bulk material properties, product design and performance.
  • Basic understanding of intellectual property protection and regulatory aspects pertaining to solid forms.