Bristol-Myers Squibb Company

Scientist I, Protein Engineering (4)

Location
Redwood City, CA, US
Posted
Aug 28, 2018
Ref
R1507847
Required Education
Doctorate/PHD/MD
Position Type
Full time
Scientist I, Protein Engineering

Job Description:
We are seeking a skilled and enthusiastic Protein/Antibody engineer to join the Protein Engineering Group. The candidate will be expected to work on a variety of protein engineering projects to optimize and generate differentiated antibody therapeutic leads.

Specific Responsibilities:
• Optimize and develop novel yeast display based methods antibody engineering and epitope mapping
• Optimize variable and constant domains of antibodies to generate therapeutic leads
• Lead protein engineering efforts to engineer antibodies with novel properties
• Elucidate mechanistic understanding of targets and work to progress targets through pipeline
• Independently perform complex experiments with strong attention to detail and documentation.
• Excellent written and oral skills are necessary.
• Accomplish goals under project team time lines.

Requirements:
• Ph.D. in Biochemistry, Antibody engineering, chemical engineering, structural biology, or similar fields with 2-5 years post Ph.D. experience.
• Extensive experience in utilizing yeast display technologies
• Experience in other display technologies (phage, mammalian systems) is a plus
• Knowledgeable in engineering novel functionalities into antibodies (such as modulating FcgRs, or FcRn interactions, multispecific antibodies etc.)
• Experience and knowledge of molecular biology, protein expression, purification, and characterization required.
• Immunology/Oncology experience including in-vitro cell-based assays is highly desirable
• Understanding of structure-function of proteins is a plus
• Excellent time management and organizational skills.
• Demonstrated ability to work in a multidisciplinary biologics discovery team.