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- Create novel experimental designs for mechanistic toxicology studies designed to assess hypotheses for and evaluate mechanisms of toxicity related to physiological or biochemical functions.
- Support predictive toxicology experimental efforts within Discovery (e.g., in vitro cell-culture based, animal models of disease) analyze safety-related data and use it to make decisions.
- As a Discovery Working Group representative, the individual will develop early safety assessment evaluations and early hypotheses about mechanisms of toxicity, ensure appropriate toxicology studies and liability screens are performed to support nomination of drug candidates for further development.
- Participate in issue-resolution teams, where she/he will contribute to hypotheses generation and drive the science for toxicology issue resolution in drug discovery and development.
- Communicate results clearly and concisely in both oral and written reports.
- Perform in depth pathway/network analysis on data derived from toxicology and other studies and disseminate results to the wider toxicology community (internally and externally).
- Closely interact with scientists in other functional areas.
This position will require broad-based knowledge of toxicology, with emphasis on investigating molecular mechanisms of toxicity. A Ph.D. in toxicology or other appropriate field is required, and postdoctoral experience is preferred. This is an entry level or early career position, and no experience in the pharmaceutical industry is required. The candidate should possess strong skill sets related design and implementation of investigative toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic translational toxicology studies, with a particular emphasis on comparative biology. The candidate should also have demonstrable competency in directing exploratory toxicology studies that support de-risking of innovative drug targets and modalities and non-clinical compound candidate selection. The individual should have a creative mindset and interest in developing strategies and directing innovative approaches to measure target modulation in (normal tissues) including genetic and pharmacological validation tools. Experience in leveraging and integrating gene expression and genomics data as well as cellular approaches to identify and advance programs is desired. A related expertise is demonstrable capability in innovative techniques emerging from organotypic, in vitro systems and genetic modification. Experience with gene manipulation editing (RNAi, CRISPR) or image analysis is a plus.