Associate Scientist/Scientist, Immuno-oncology

Location
South San Francisco, California
Posted
Aug 27, 2018
Required Education
Bachelors Degree
Position Type
Full time

ABOUT THE COMPANY:

Compugen USA, Inc., a wholly owned subsidiary of Compugen Ltd., develops therapeutic antibodies for the treatment of cancer. Working closely with colleagues in Israel, we are advancing multiple programs targeting novel immune checkpoint inhibitors and immune modulators for reactivation of anti-tumor immune responses. We’re seeking highly skilled and motivated employees who are looking for growth opportunities in a fast paced, startup-like environment.

SUMMARY OF JOB DESCRIPTION:

We are seeking a highly motivated Associate Scientist or Scientist to join our Immuno-Oncology team and participate in the development and characterization of immune-targeting antibodies for cancer therapy. Responsibilities include development and optimization of innovative cell-based assays to assess antibody activity and potency, optimization of these assays for antibody screening, and characterization of lead antibodies to define mechanisms of action. Proficiency in immune cell phenotyping, multi-color flow cytometry and other immunology related assays is preferred. The candidate must be willing to expand his/her knowledge of biology and experimental techniques. In this position, the candidate will serve a critical role in the identification of lead antibodies and the discovery of novel drugs and their effects on target biology in the field of immuno-oncology.

 

ESSENTIAL JOB FUNCTIONS & ACCOUNTABILITIES:

• Develop and optimize T cell and myeloid cell-based assays for the identification and characterization of therapeutic antibodies

• In a cross functional setting, execute antibody screening and characterization that will result in lead antibody identification

• Play a key role in the development and enhancement of core technologies related to cellular assays

• Support immune cell phenotyping of normal and tumor tissue samples using multi-color flow cytometry

• Develop and maintain an up-to-date understanding of oncology/tumor immunotherapy literature and methodology, as well as the literature related to specific antibody discovery projects by presenting data from high impact journal articles at team meetings

• Prepare and organize data for presentation; present written and oral reports to the project team, Antibody R&D group, and management

• Collaborate with project Leaders, prioritizing efforts to ensure timely progress in research projects

 

EDUCATIONAL QUALIFICATIONS:

• Bachelors, Master, or Ph.D. in Biology or related field

 

EXPERIENCE QUALIFICATIONS:

• 6 years (Bachelors), 4 years (Masters), or 0-3 years (Ph.D.) industry experience involving the development of therapeutic antibodies

• Proven record of success in developing and implementing assays for antibody function and potency screens

• Prior experience with cell-based assays relevant to immunology or cancer drug development (immune cell expression profiling, signaling, proliferation, cytokine secretion, cellular cytotoxicity, ADCC, etc.)

• Proficiency in FACS and relevant plate and bead-based assay systems (ELISA, Luminex, etc.)

• Scientific background in oncology or immunology is preferred

• Track record of scientific accomplishment as evidenced by quality and quantity of publications and/or inventions (PhD level candidates)

• Demonstrated ability to independently manage functional responsibilities on therapeutic project teams

 

SKILLS REQUIREMENTS:

• Thoughtful experimental design and comprehensive note keeping

• Excellent written and verbal communication skills are required

• Ability to prioritize and manage multiple projects and activities

• Ability to work independently and proactively address/troubleshoot problems

• Maintain excellent working relationships with colleagues and collaborators

• Ability to work productively with colleagues across the global company and to travel (up to 5 %)

• Well organized, efficient and systematic

 

SHOULD BE INTERVIEWED BY:

Hiring manager, IO team, Global VP of HR