Senior Scientist II, Protein Purification, Discovery, Global Biologics

Worcester, MA, US
Aug 26, 2018
Required Education
Bachelors Degree
Position Type
Full time
T he Global Protein Sciences (GPS) Group in Discovery is seeking a highly motivated Senior Scientist to join its Protein Purification Group at AbbVie Bioresearch Center in Worcester, MA. As a member of the group, the candidate will be responsible for working in cross functional teams with other scientists in various therapeutic areas as well as the Biologics generation group in Worcester to advance the pipeline. The successful candidate will have experience in protein engineering and purification of immunogens and therapeutics with a good understanding of technologies for generating proprietary biotherapeutics.

Key Responsibilities Include:

  • Design alternate therapeutic formats (Multi-specifics, Non-Ig Scaffolds etc.), fusion proteins, immunogens from concept using computational tools (Rosetta/pymol/others) and execute through experimental production and characterization
  • Enable progression of targets through the pipeline with appropriate reagents that elucidate a mechanistic understanding of target biology
  • Design, express, purify and characterize soluble and membrane protein targets with enhanced expression and stability enabling functional studies and antibody discovery
  • Purify integral membrane proteins/complexes for querying target biology, therapeutic development and structural studies.
  • Introduce and lead innovative science enabling publication and external presentations

  • BS, MS or PhD with a strong foundation in biochemistry, protein purification, structural biology, and at least 12-14+ (BS), 10-12+ (MS) or 4-6+ (PhD) years of post-graduate experience in protein design and purification
  • Significant research experience as demonstrated by a track record of publications and scientific accomplishments
  • Experience with commercially available automated purification systems
  • Experience with expression and purification from various host expression systems such as mammalian (HEK/CHO), insect/baculovirus and E.Coli.
  • Experience in display technologies (phage, yeast) is a plus
  • Demonstrated ability to work with multidisciplinary biologics groups in a fast paced discovery team setting
  • Participation in project teams and effective communication with team members throughout the organization.
  • Highly developed leadership skills and ability to engage collaborators across the organization

Equal Opportunity Employer Minorities/Women/Veterans/Disabled