Scientist I/II, Liver Biology

Location
Cambridge, Massachusetts
Posted
Aug 24, 2018
Discipline
Science/R&D, Biology
Required Education
Doctorate/PHD/MD
Position Type
Full time

Wave Life Sciences USA seeks an experienced and highly motivated Scientist to join its research team in Cambridge, Massachusetts.  This is an ideal position for an individual with a strong background in liver biology and metabolic diseases who thrives in a team-oriented, fast-paced, and cross-disciplinary biotech environment.  The candidate will be responsible for designing, executing and analyzing experiments, as well as leading scientific teams focused on therapeutic programs and discovery research platforms.  This candidate will contribute to all levels of in vitro and in vivo discovery research to support development of optimized nucleic acid therapies in liver disease areas.

Responsibilities:

  • Develop, design and execute in vitro and in vivo assays.
  • Identify and validate new targets and develop drug candidates with focus on hepatic and metabolic diseases
  • Analyze, interpret, and draw conclusions supported by screen of antisense drug candidates, communicate findings effectively through written reports and oral presentation

Education / experience required:

  • Ph.D. in Cell/Molecular Biology, Pharmacology, or related field with 2-5 years of postdoctoral experience.
  • Strong experience in liver biology and metabolic diseases
  • Expertise in molecular biology techniques including RNA extraction from tissues/cells, qPCR, protein analysis (western blots, ELISA) and enzyme activity.
  • Experience with mammalian cell culture systems and cell-based assays.
  • Knowledge-base of antisense or related therapeutic approaches.
  • Outstanding ability for experimental design and execution, efficient assay development and creative problem solving.
  • Adept at preparation of clear and accurate reports for internal and external projects.
  • Capacity to be highly productive in a fluid and fast-paced work environment.
  • Committed and collaborative team player.

Experience preferred:

  • Prior experience with animal models of human hepatic and metabolic diseases is strongly preferred.
  • Experience in drug discovery and early drug development is desired.