Temp Research Associate I, RGC Sequencing and Lab Operations

Location
Tarrytown, New York, US
Posted
Aug 23, 2018
Ref
14067BR
Required Education
Bachelors Degree
Position Type
Contract
Position Summary

The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development.

We are looking for a Research Associate - Sample and Library Preparation, who will report to the Senior Manager - Sequencing and Lab Operations. This Research Associate will be responsible for preparing human DNA samples for genotyping and exome capture on our custom automation platforms.

Responsibilities
- Receiving DNA samples from collaborators, logging samples into our database, and storing samples in our biobank
- Operating our custom robotic platforms to create DNA libraries for exome capture and genotyping
- Logging sample information into our library information management system (LIMS)
- Performing sample quality control (QC) assays using gel electrophoresis, UV spectrometry, fluorometry, and quantitative real-time PCR
- Monitoring QC data and identifying samples not meeting our established standards for passing QC values
- Troubleshooting procedures related to sequencing library construction
- Collaborating with our engineering and automation core teams to test new methods related to sequencing library construction
- Validating and implementing new technologies introduced at the Center
equirements
This position requires a minimum of a Bachelor's Degree and some experience working in a molecular biology lab.

Preferred experience would include:
- Familiarity with next-generation sequencing approaches and technology
- Using a library information management system (LIMS); exceptional candidates will have prior experience with Sapio Exemplar LIMS
- Various molecular biology techniques such as PCR, gel electrophoresis, and quantitative real-time PCR.
- Operation of an automation platform (e.g. a liquid handling robot); a good candidate will have prior experience with Hamilton robotics
- Familiarity with standard DNA laboratory QC instruments (e.g. UV spectrometer, microplate reader, Agilent Bioanalyzer, LightCycler 480).

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.