Associate Principal Scientist, Biology-Discovery

Palo Alto, California
Aug 09, 2018
Required Education
Bachelors Degree
Position Type
Full time

Date: Jul 14, 2018
Location: Palo Alto, CA, US
Requisition ID: BIO005156

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
The Biologics Discovery organization seeks an outstanding candidate to join the Biotherapeutics Discovery Group. This Associated Principal Scientist will work on target identification and biotherapeutics lead identification utilizing multiple strategies and platforms. The candidate will have demonstrated success in designing functional assays and performing antibody phenotypic screens to identify biologics leads. This work will advance large-molecule research programs from target validation through to pre-clinical candidate selection. Broad expertise in molecular and cellular biology is required with preference given to candidates with demonstrated experience working with clinical samples and advancing biotherapeutics to the clinic. The successful candidate will have excellent oral and written communication skills, will work well both independently and as part of a team, and will be able to work on multiple projects simultaneously and have experience managing lab personnel. With supervision the role includes planning, designing, and developing new methods and executing projects utilizing good scientific judgment. The position is a hands-on, laboratory-based role and will have direct report(s).

Education Minimum Requirement: 
Bachelor’s degree with a minimum of 12 years of industry experience within biologics drug discovery OR a Master’s degree with a minimum of 8 years of industry experience within biologics drug discovery or PhD degree in biological sciences with a minimum of 4 years of industry experience within biologics drug discovery

Required Experience and Skills: 
• Advanced molecular biology skills, including demonstrated success in library design and cell line engineering for functional antibody screening
• Advanced cellular biology experience including engineering and ex-vivo primary cell assays
• Experience with bioinformatics and genomics including data analysis and visualization
• Must be able to work independently
• Work plan design and managing external projects at CRO

Preferred Experience and Skills:
• Experience in one or more of the following therapy areas:
  o Oncology
  o Immunology
  o Cardio-metabolic and renal diseases
  o Infectious disease
  o Neuroscience
• Demonstrated track record of Biotherapeutics lead discovery of clinical candidates
• Experience working with clinical samples
• Experience with flow cytometry
• People management
• Project management
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 
If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to
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Visa sponsorship is not available for this position.