Director / Scientist, Antibody Discovery and Engineering

San Francisco, California
Aug 09, 2018
Required Education
Position Type
Full time

Director / Scientist, Antibody Discovery and Engineering

This is a great opportunity to join the experienced scientific team at QLSF Biotherapeutics, an innovative immuno-oncology biotech startup in South San Francisco.  We are expanding our teams with multiple positions to support discovery research of next generation antibody-based therapeutics.  Position/Title commensurate with education and experience.

The candidate will be expected to work on multiple protein engineering projects simultaneously and deliver results in a timely manner. Expertise in multi-specific antibody platforms, Fc engineering, and developability. Ability to think creatively to generate best-in-class therapeutic leads. Provide scientific and technical input to guide pipeline development.


  • Ph.D. in immunology, molecular biology, cell biology, or biochemistry with lab experience. Preferred candidates will have therapeutic discovery experience in the biotech industry.
  • Deep understanding of antibody structure and biology to generate well-behaved, potent antibody therapeutic leads.
  • Appropriate skills include molecular cloning, hybridoma sequencing, sequence analysis, and recombinant antibody expression constructs.
  • Appropriate skills in antibody characterization including kinetic binding and thermal stability.
  • Excellent team player, capable of thriving in a fast paced, highly collaborative, dynamic work environment.
  • Excellent organization skills, planning and record keeping.
  • Candidates with structural biology and protein modeling is a plus.
  • Humanization of antibody variable domains is a plus



QLSF Biotherapeutics offers a competitive compensation package, including comprehensive benefits, stock options, as well as a 401(k)-retirement savings plan.