Biophysical Associate Scientist/Scientist, Small Molecule

94080, South San Francisco
Aug 07, 2018
Required Education
Position Type
Full time

Join a Team that Lives to Improve Lives

People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in our South San Francisco, CA headquarters:

Biophysical Associate Scientist/Scientist, Small Molecule


Genentech Research and Early Development (gRED)  is seeking a talented biophysical Scientist to join the Biochemical and Cellular Pharmacology Department supporting our small molecule drug discovery pipeline. In this position you will have opportunities to further develop your skill set and advance your scientific contribution to the drug discovery community.  Genentech provides a rich collaborative environment and a “science-first” spirit where research often moves quickly from discovery-to-publication in top-rate scientific journals. We invest in scientific talent, our managers nurture that talent, and with our continued development of state-of-the-art technology, our scientists have every opportunity to maximize their potential. This enhances our ability to develop medicines to treat patients with serious, or life-threatening, medical conditions.


  • Support small molecule project teams using biophysics with a focus on SPR, for hit identification, validation, progression, and mechanistic studies.
  • Provide strong technical leadership to project teams in designing appropriate assay cascades
  • Manage available resources effectively to achieve project goals
  • Contribute to Genentech’s culture of discovery and innovation via presenting regularly at the functional level and by collaborating with colleagues.


Who You Are

  • PhD in biophysics, or a related field, with up to 4 years of relevant drug discovery experience beyond PhD.
  • Experience in the application of Surface Plasmon Resonance (SPR), or equivalent label-free technology, to small molecule drug discovery
  • Strong communication and presentation skills for helping to support identification of potential challenges, collaborative troubleshooting and delivery of both timely and impactful data.
  • Proven record with significant contribution(s) to drug discovery related research as evidenced by a strong publication record.
  • Broad understanding of the hits-to-leads process.
  • Comfortable participating in and/or leading multidisciplinary teams across functional areas.
  • Working knowledge of other biophysical techniques and a record of advancing drug discovery methods highly desired
  • Experience in SPR-based fragment screening and associated follow-up is highly advantageous.
  • Familiarity with kinetic /thermodynamic characterization by label-free methods is helpful.


A Job with Benefits Beyond the Benefits

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.