Scientist, In-Vitro Cell Biologist

Employer
AbbVie
Location
Worcester, MA, US
Posted
Jul 31, 2018
Ref
1805491
Required Education
Bachelors Degree
Position Type
Full time
AbbVie has an opening for an In Vitro Cell Biologist within the Antibody Drug Conjugate (ADC) Group at our Bioresearch Center in Worcester, MA. The ADC group within Global Biologics collaborates with drug discovery project teams across all AbbVie therapeutic areas including Oncology and Immunology. The ideal candidate will effectively work to collaborate with chemists, biologists and pharmacologists to characterize large and small molecules for ADC development.

Key Responsibilities:

  • Lead the design and execution of in vitro assays for screening of biologics, small molecules and antibody drug conjugates
    • Reporter, cytokine release and antibody internalization assays
  • Generate and characterize transient and stable cell lines to support antibody drug conjugate programs.
    • Lipid transfection and lenti viral infections
  • Characterize lead molecules and confirm mechanism of action
  • Work collaboratively with T.A to deliver targets across portfolio
  • Demonstrate scientific excellence, work ethic, and dedication to team and project goals
  • Work collaboratively in a matrix with project teams and members of the Biologics Group to drive innovation and deliver novel therapies to patients
  • Develop productive collaborations and communication with other groups across therapeutic areas


Basic:

  • BS degree in related discipline with 5-7+ years of experience or MS degree in related discipline with 2-5+ years of experience
  • Experienced screening large and small molecules (reporter assays, proliferation and cytokine release)
  • Experience executing antibody internalization experiments
  • Experience with transfections and generating transient and stable cell lines
  • Experience culturing adherent, suspension and primary cells
  • Proficiency in performing flow cytometry and ELISA experiments
  • Experience with performing qPCR and automated western blot analysis
  • Experience working with high throughput laboratory workflows and instruments such MACsQuant, FACS Canto, Microbeta, Wes, Amnis Imagestream, Via7 (taqman) and Spectramax plate readers.
  • Experience documenting experimental methods and results into BIOELN
  • Ability to summarize and present results to project teams

Preferred:
  • BS in related discipline with 7 years industry experience

Key AbbVie Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
  • Learns fast, grasps the "essence" and can change the course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.


Equal Opportunity Employer Minorities/Women/Veterans/Disabled