Senior RA or Associate Scientist: Cell Line Development & Upstream Process Development

Location
98052, Redmond WA
Posted
Jul 30, 2018
Required Education
Bachelors Degree
Position Type
Full time

Senior RA or Associate Scientist: Cell Line Development & Upstream Process Development

Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.

Job Summary:

This individual will work in Cell Science and Upstream team. Major responsibilities include transient and stable transfection with multiple mammalian cell lines, cell line development, CHO cell  shake-flask process optimization, bioreactor production, and primary recovery operations.  Detailed record keeping, data analysis, report generation, and participation and presentation at group meetings are included in job function.  The position requires familiarity with biologics therapeutic production processes and analytical methods operations in the pharmaceutical industry. 

Job Requirements:

  • Establish CHO cell line development process for a range of recombinant proteins and antibodies of multiple scaffolds for research, discovery and clinical development.
  • Conducts routine analytical assays to assess protein quantity.
  • Develops robust mammalian cell culture bioprocess for internal protein production.
  • Performs cell line development and clonal selection for lead candidates.
  •  Implement upstream processes using micro and small bioreactors for production and analysis of in housed generated recombinant antibodies from CHO stable line
  • Assure cGMP compliant cell line development and cell banks for production of research, toxicology and clinical material to meet project timelines. Establish relevant cGMP documents to support successful implementation of process technology in clinical/commercial manufacturing operations
  • Technology transfer to CMO to support drug substance manufacturing and follow-on support
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Bachelor in Life Science or related field with 5-10 years of industry experience in mammalian cell culture.