Associate Scientist, Neuroscience, Alzheimer's Disease

Cambridge, MA, US
Jul 27, 2018
Required Education
Bachelors Degree
Position Type
Full time
AbbVie has established the Foundational Neuroscience Center (FNC) in Cambridge, MA to investigate the fundamental biological mechanisms and to develop therapeutic interventions for neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

The Tau Biology group is seeking a highly motivated applicant with prior experience and expertise in target validation and assay development in neuroscience. The Scientist will support a project leader in 1) CRISPR / Cas9 screening, 2) perform multiplexed image-based screening studies of small molecules and inhibitors of tau aggregation in neurons.

Key Responsibilities Include:

  • Analyze human AD brain tissues and extract protein of interest using western blot, MSD, and other biochemical assays
  • Culture hiPSC (human-induced pluripotent stem cell) neurons and rodent primary neurons
  • Design and perform tau aggregation inhibition studies in neuronal cultures using high-content, high-throughput robotic-assisted imaging, multiplexed imaging, and confocal microscopy. Analyze and present the results to validate novel drug targets.
  • Work diligently and efficiently to meet deadlines in a fast-paced environment.
  • Read and apply relevant scientific literature.

  • B.S or MS degree in System Neuroscience or related field with 0-3+ (BS) or 0+ (MS) years of experience. Industry experience preferred.
  • Proficiency with standard cell biology, biochemistry, and microscopy methods.
  • Expertise in developing biochemical and cellular assays for high throughput screening.
  • Familiarity with plate readers and/or high content imaging / familiarity with neuroanatomy is plus but not required.
  • Comfortable using computer programs such as Microsoft, Google Docs, Microsoft Excel, etc.
  • Highly motivated, detailed oriented, curious of the science, and desire to learn to novel neuroscience techniques.
  • Demonstrate critical thinking, independence, clear scientific writing & verbal communication skills and precise record keeping
  • Strong organizational skills that facilitate planning, multitasking and working within timelines.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled