Bristol-Myers Squibb Company

Associate Director/Director - Antibody B-Cell Cloning (32)

Location
Redwood City, CA, US
Posted
Jul 27, 2018
Ref
R1507891
Required Education
Doctorate/PHD/MD
Position Type
Full time
Associate Director/Director - Antibody B-Cell Cloning
We are looking for a highly motivated leader to lead the molecular rescue effort within the antibodies lead generation group. This is an exciting opportunity to make a significant impact within a department that is driving the biologics therapeutics pipelines in BMS. In this role the scientist is expected to develop and use the single B cell cloning and other recombinant platforms to expedite the process and deliver high quality lead molecules.

Major responsibilities:

• Develop and optimize the existing single B cell cloning workflow. Expand the scope of applications of single B cell protocol and harmonize it with associated supporting platforms.
• Explore B-cell encapsulation and display methods to capture immune diversity.
• Fully integrate molecular rescue into antibody lead generation pipelines.
• Be a champion in the lead discovery process and collaborate with biology project leaders closely to progress respective pipelines.
• Stay informed and contribute to the vision in the technology development space especially in single cell analytics and gene capture.
• Excellent written and oral skills are necessary
• Accomplish goals under project team time lines

Qualifications:

• Ph.D. in molecular biology or immunology with 6-8 years of industry experience or an advanced degree with 10+ years of relevant experience.
• High proficiency in all critical molecular biology techniques with focus on high throughput, high sensitivity gene rescue from single cells or tissues of interest. Past experience with antibody V gene rescue from B cells is required.

• Having experience with hybridoma is highly desirable.

• Experience with leading a team is required.
• Proficiency in cell biology skills such as FACS. Target-centric cell sorting or selection experience is a plus.
• Proficiency in large dataset analysis.
• In-depth knowledge of B/T cell biology and humoral and cell mediated immune responses.
• Highly innovative and self-motivated.
• Excellent time management and organizational skills.
• Demonstrated ability to work in a multidisciplinary biologics discovery team.