Sr Scientist Molecular Genomics – Early Target Discovery

San Diego, CA
Jul 26, 2018
Required Education
Masters Degree/MBA
Position Type
Full time


Takeda is a global, innovation-driven pharmaceutical leader with 30,000 professionals working together across more than 70 countries. We have maintained an unwavering dedication to put patients first for more than 235 years while we live our values of Takeda-ism—Integrity, Fairness, Honesty, and Perseverance. We are united by our mission to strive towards Better Health and a Brighter Future for people worldwide through leading innovation in medicine.

We focus our research and development on the core therapeutic areas of oncology, gastroenterology, neuroscience, and on providing vaccines that address the most important infectious diseases. Novel products, especially in oncology and gastroenterology, as well as our presence in emerging markets, fuel our growth.

Takeda California generates highly disease-specific and patient-tailored transformative new medicines aligned with Takeda’s global market strategies through research in Gastrointestinal (GI), Neuroscience and Immunology. Takeda California’s team of experienced scientists and clinicians deliver on the needs of patients by blending its internal capabilities, global Takeda resources, and expertise and technology from best-in-class external partners. In early 2019, Takeda California will open a new 165,000 square-foot building with the intent to make it an external innovation and collaboration hub for San Diego.


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Job Description


The Senior Scientist, Molecular Genomics within Early Target Discovery is responsible for functional characterization of SNPs and genetic variants associated with diseases aiding target identification and validation (TIDVAL) in Takeda’s Research in support of initiating drug discovery programs. Utilizes cutting edge molecular and high throughput technologies for functional characterization of disease associated SNPs, genes, miRNAs, microproteins, splicing, or transposons. Studies mechanistic basis of causal and protective variants association to diseases.


  • Employs a multi-disciplinary approach, combining genome engineering, pooled genetic screens, bioinformatics, electrophysiology, and imaging, to dissect the inner workings of the human genome and pathogenic mechanisms 
  • Designs and implements functional characterization strategies for disease associated SNPs/variants identified from patient genetics
  • Responsible for high throughput molecular biology work streams in TIDVAL
  • Identify opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities.
  • Proposes, designs, and executes in vivo and in vitro studies to support Takeda programs.
  • Works and communicates effectively with colleagues of differing backgrounds and experience levels
  • Provides analysis and interpretation of data; writes study reports and presents data effectively in all settings and with participants of all levels of the organization.
  • Keeps up to date with appropriate literature and scientific developments and uses knowledge to propose new programs or support current programs
  • Represent own research findings to leadership and project teams.
  • Professionally represents the organization in collaborations, partnership discussions, and external conferences.


  • Ph.D. in molecular biology or molecular genetics or bioengineering or related discipline with 4+ years of combined post-doctoral, biotech/pharma industry experience and publication record OR
  • MS in Life Science with 14+ years of relevant experience and publication record.
  • Extensive hands-on experience in some of the techniques with human biopsies: HT molecular biology, recombinant expression, RNAseq, whole genome/exome sequencing, HT genome-wide CRISPR editing, mRNA splicing, modulation of miRNA and microprotein expression, IHC, 2D-DIGE, etc.
  • Track record of working on complex problems, and ability to integrate data from multiple disciplines
  • Strong interpersonal, collaboration skills to work in a team-oriented, fast-paced, matrix environment, and the ability to work through conflicts
  • Highly motivated and flexible with a positive can-do attitude
  • Ability to provide novel creative solutions to challenging problems
  • Desire to learn and tackle new challenges and initiatives


  • None required  


  • Working in cold room (4°C)
  • Able to lift or move up to 10 pounds on a regular basis during daily work.
  • Exposure to hazardous/toxic/dangerous chemicals


  • Less than or equal to 5% travel, consisting of one to two relevant scientific meetings and/or trips to meet with collaborators and CROs


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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