Senior Associate Scientist, Bioinformatics

Location
Cambridge, MA, United States
Posted
Jul 26, 2018
Ref
1105815
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
Join bluebird bio's enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach. Bluebird's dynamic Genomics group combines expertise in computer science, statistics, molecular biology and human genetics. The hire will partner with biologists to analyze the next-generation sequencing (NGS) data coming from both external databases and in-house sequencing instruments. This position is a chance to leverage bioinformatics, statistics and data science to make an immediate impact on the efficacy and safety of future gene therapy products.

About the Role:
  • Improve and automate megaTAL nuclease off-target profiling workflows
  • Apply machine learning methods to predict megaTAL off-target activity and correlate it to structure of the protein
  • Develop and maintain pipelines related to total RNA and mRNA sequencing, bulk and single cell, evaluate different single cell platforms
  • Visualize the data to explain the findings to a large cross-functional team and/or the outside stakeholders
  • Learn about the needs of the biology teams and proactively suggest new ways the bioinformatics team can impact research and discovery projects


About You:
  • BS with at least 5 years of experience or MS with at least 3 years of experience
  • Excellent command of Python, candidates will be asked to complete a short coding assignment in Python as part of the initial screen
  • Working knowledge of R, shell scripting and git version control
  • Understanding of molecular biology and being able to communicate with cross-discipline project teams
  • Knowledge of core concepts data analysis and applied statistics - model testing, regression, classification and clustering methods
  • Excellent organizational skills, sufficient to multi-task in an extremely fast-paced environment with changing priorities
  • Excellent communication skills and ability to influence across multiple functions
  • Be ready to embrace the principles of the bluebird bio culture: b colorful, b cooperative, and b yourself