Scientist, Immunoassay Development

Location
Cambridge, MA, United States
Posted
Jul 26, 2018
Ref
967113
Hotbed
Genetown
Required Education
Masters Degree/MBA
Position Type
Full time
Vector Analytics - Immunoassay/ Bioassay Development

bluebird bio is developing potentially transformative, one-time gene therapies for severe genetic and orphan diseases. At the heart of bluebird bio's product creation efforts is its broadly applicable gene therapy platform for the development of new treatments for diseases with few or no clinical options. bluebird bio has two clinical stage product candidates in development, one for childhood cerebral adrenoleukodystrophy (CCALD) and one for beta-thalassemia major/sickle cell disease, and an early stage oncology program in partnership with Celgene Corporation.

Join bluebird bio's enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach. The focus of this position is to provide support for the characterization of lentiviral vector. We are looking for an innovative scientist with the breadth of experience and drive to implement our vision for this function.

About the position:
  • Support the development of analytical assays for biochemical and biophysical characterization of lentiviral vectors, plasmids, and residual impurity analysis.
  • Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
  • Support assay qualification and validation activities and interact with CMOs and other vendors, as required.
  • Cross-functional and highly visible position, requires active collaboration with the vector process development, research and quality teams.
  • Provide expertise on multiple techniques to support trouble shooting and enhancing of existing assays.
  • Develop novel potency assays for broad range of severe genetic disease and cancer therapeutics for gene therapy and gene editing programs.
  • Devise experiments for advancing LVV and gene editing understanding.
  • Support analytical sections of regulatory filings for US, Europe and ROW.

About you:
  • MS/Ph.D. in immunology, cell biology or related sciences with 0-2 years (Ph.D.) or 4+ years (MS) of relevant experience in industry.
  • Expertise in T-cell biology, cancer immunotherapy and/ or hematopoietic stem cell biology, gene therapy research is required.
  • Extensive hands-on experience in development of cell-based-, biochemical- and immunoassays using techniques like flow cytometry, ELISA, Luminex, etc. is required.
  • Experience with qualifying and validating assays and an understanding of ICH/ FDA guidelines is preferred.
  • Prior experience of working with either lentiviral vectors or virus-like particles is preferred.
  • Experience in working with and managing external vendors/ CROs is a plus.
  • Excellent organization skills, sufficient to multi-task in a fast-paced environment with changing priorities. Must be able to work effectively as part of a multi-disciplinary team.
  • Understanding of statistical tools, such as JMP, DoE, Prism etc. will be a plus.
  • Track record of completing deliverables within specified timelines and "do-what-it-takes" attitude.
  • Superb communications-both written and oral skills.
  • Independently motivated, detail oriented and good problem-solving ability.
  • Be ready to embrace the principles of the bluebird bio culture: b colorful, b cooperative, and b yourself