Associate Scientist - Cellular Process Development

Location
Cambridge, MA, United States
Posted
Jul 26, 2018
Ref
1260701
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
Associate Scientist, Cellular Process Development

Novel Gene Therapy Platforms

9 Month Contract

Join bluebird bio's enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach. The Process and Analytical Development organization at bluebird bio encompasses lentiviral vector, gene editing, and cellular drug product processing for oncology and severe genetic diseases. The cellular process development team is responsible for developing cellular drug product processes and introducing new technologies for stem cell and T cell therapies. The focus of this position is to provide support for the development of manufacturing processes for engineered T cells. We are looking for a motivated associate scientist with the experience and drive to take ownership over important process development projects.

Activities include:
  • Assist in the design and testing of new equipment and technologies for closed system manufacturing of autologous cellular therapies
  • Assist in developing, improving, and executing procedures for the isolation, transduction, gene editing, expansion and cryopreservation of autologous cells for engineered T cell processes.
  • Perform complex technical work related to cell biology, gene transfer, and molecular biology, including tissue culture, flow cytometry and qPCR
  • Responsible for maintaining inventories and archiving experimental samples
  • Assist in the review and editing of standardized procedures
  • Must be willing to have a flexible schedule based on experimental and company needs
  • Performance of general laboratory tasks, including maintenance of equipment
  • Maintain accurate and reliable record keeping including database management, batch records, notebooks, and all other pertinent documentation

Preferred Qualifications:
  • BS or MS in cell biology, immunology or related discipline with at least 2years' experience in the biotechnology or pharmaceutical industry. Experience with cGMP manufacturing of Phase I/II cellular and gene therapies is a plus
  • Multicolor FACS staining and operating various types of flow cytometers preferred.
  • Experience with electroporation preferred.
  • Have superb aseptic technique, and experience with isolating, and culturing primary cells
  • Willingness to work with lentiviral vector and human biological samples including leukapheresis and whole blood
  • Ability to take ownership of projects and results
  • Independently motivated, detail oriented and good problem solving ability
  • Excellent organizational skills, sufficient to multi-task in a fast-paced environment with changing priorities
  • Strong verbal and written skills; ability to provide focus and clarity; able to handle confidential information and material appropriately
  • Working knowledge of various computer software, hardware, and standard office, sufficient to record scientific data and results, and prepare reports.
  • Ability to work in a team environment, meet deadlines, and prioritize and balance work
  • Be ready to embrace the principles of the bluebird bio culture: b colorful, b cooperative, and b yourself