Scientist- Process Development Pivotal Drug Substance

Employer
Amgen
Location
Cambridge, Massachusetts
Posted
Jul 25, 2018
Ref
R-54958
Required Education
Bachelors Degree
Position Type
Full time

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for

solutions that improve health outcomes and dramatically improve people's lives. A

biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading

independent biotechnology companies, has reached millions of patients around the world

and is developing a pipeline of medicines with breakaway potential.

The Pivotal Drug Substance Technologies organization at Amgen develops, characterizes and supports the commercialization of the drug substance manufacturing processes for all late-stage programs across the Amgen portfolio.

Located at our Cambridge, MA site, the Scientist will be responsible for the development, characterization, scale-up and support of upstream and downstream processes to enable commercial advancement of programs from Ph II/III clinical trials to marketing application.

Responsibilities:

Work in an integrated group in which cell culture and purification scientists work together to advance Amgen's rich, exciting and dynamic pipeline.

Work on multiple modalities from antibodies and oncolytic viruses to bispecifics and siRNAs.

Apply established platform approaches and utilize solid problem-solving skills to rapidly solve purification challenges and build robust processes with efficient experimentation.

Drive new approaches and utilize out-of-the-box thinking to contribute to technology development.

Demonstrate the desire to expand and develop skills in cell culture, thereby further contributing to the integrated group.

Basic Qualifications:

Doctorate degree or PhD completed by June 2018

OR

Master's degree and 4 years scientific experience

OR

Bachelor's degree and 6 years scientific experience

Preferred Qualifications:

Doctorate in Chemical Engineering, Biochemical Engineering, or other relevant sciences

Proven track record problem solving and trouble-shooting protein purification processes, preferably in a process development environment

Strong understanding and extensive hands-on experience in protein chromatography,

including affinity, ion exchange, and hydrophobic interaction chromatography

Experience in filtration operations, including ultrafiltration/diafiltration (UF/DF)

Demonstrated ability to independently identify, develop and implement scientific solutions to practical problems

Motivated self starter with excellent interpersonal and organizational skills

Leadership experience of progressively increased scope and a demonstrated ability to inspire and lead a group of scientists to deliver on complex and challenging objectives in defined timelines

Demonstrated eminence in the scientific community through a sustained record of peer reviewed publications; Excellent verbal communication and scientific writing skills

Demonstrated success working with diverse team members in a dynamic, cross-functional environment

Familiarity with design of experiments and statistical analysis of data