Director, Assay Development

Location
Spring House, PA
Posted
Jul 19, 2018
Ref
6271180318
Required Education
Doctorate/PHD/MD
Position Type
Full time

Description:

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Director, Assay Development to be located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.

Please visit http://www.janssenrnd.com/ for more information.

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.

The new Lead Discovery team is a critical part of the Discovery Sciences organization in Janssen R&D and is committed to the delivery of high quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area discovery teams. This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners.

The Screening department within Lead Discovery is responsible for the delivery of small-molecule qualified hits for the initiation of hit-to-lead programs within the Therapeutic Areas. Major activities include HTS assay development, screening and compound profiling. The Screening Team collaborates closely with Janssen Therapeutic Areas and functional teams, the Innovation Centers, and external collaborators in academia and industry. We seek individuals with a strong ability to connect key stake holders for the delivery of goals and objectives, fostering an environment of collaboration, collegiality and positive communication, and who show superior performance in the context of a multidisciplinary, geographically disperse team.

As Director, you will lead multiple assay development groups, consisting of Ph.D. and non-Ph.D. scientists. The groups will develop pharmacologically-relevant biochemical, cellular and phenotypic assays to perform HTS and perform hit validation. You will set standards for scientific excellence, and build a culture of innovation aligned with therapeutic area objectives. You will have strategic foresight to help shape the future activities of the department. You will also contribute scientifically to discussions regarding external collaborations.

In this exciting role, you will:

  • Lead the design and implementation of screening strategies that reflect the pharmacology to be modulated in subsequent hit-to-lead discovery programs.
  • Provide scientific leadership to multiple assay development groups that develop biochemical and cell based assays that are suitable for automated high-throughput screening in 384 or 1536-well formats, perform analysis of screening data and present at program team meetings.
  • Provide scientific leadership to ensure screening hits are pharmacologically relevant.
  • Contribute to the development and execution of innovative directions for the department.
  • Provide mentoring and career development leadership to direct reports and to others within the department as appropriate.
  • Collaborate across multiple therapeutic and functional areas in the US, Europe and Asia.
  • Develop innovative approaches to screening and hit triage.
  • Attend in-house seminars and external scientific meetings as appropriate.
  • Manage external collaborations.
  • Publish research in high-quality journals as appropriate.


Qualifications:

  • PhD in biochemistry, biophysics, cell biology, pharmacology or related areas is required.
  • Postdoctoral experience is preferred.
  • A minimum of 12 years of industry experience in assay development and in vitro pharmacology is required.
  • Record of success as a HTS or pharmacology group leader is required.
  • Strong capabilities to recruit, teach and develop/mentor both Ph.D. and non-Ph.D. scientists is required.
  • Expertise with assay development (384 or 1536 well) using biochemical and cellular methods is required.
  • Hit triage experience is required.
  • Experience working with and guiding external collaborators in industry or academia is required.
  • Fragment screening experience is preferred.
  • People management expertise (supervising, coaching, mentoring) is required.
  • Recent publications in high-quality peer-reviewed journals are required.
  • Expertise in cardiovascular, immunology, infectious diseases, neuroscience or oncology therapeutic areas is preferred.



Johnson & Johnson Family of Companies are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law.


Primary Location:
North America-United States-Pennsylvania-Spring House

Organization:
Janssen Research & Development, LLC. (6084)

Job Function:
R&D

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