Research Associate 1/ 2

Location
Novato, California
Posted
Jul 18, 2018
Ref
14351
Required Education
Bachelors Degree
Position Type
Full time
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin's Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin's cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients' lives. SUMMARY DESCRIPTION State the overall function or purpose of the job.

The Research Associate (RA) plans and performs activities required for immunoassay Critical Reagents preparation, and characterization; assay optimization/development; with an appropriate level of guidance. The individual will manage the development and quality of critical immunoassay reagents using established methods and techniques, ensuring accurate and complete reagent documentation to facilitate efficient data retrieval and sharing and knowledge transfer activities. This position will require collaboration with external entities as well as with other internal departments. An ideal candidate for this position should have a demonstrated ability to think critically, be highly self-motivated, and be able to work independently as well as collaborate with a team on a regular basis. The RA may present results to group meetings.

RESPONSIBILITIES List the major responsibilities of the job. • Produce consistently prepared and well characterized reagents to reduce the risk of assay failure. • Responsible for the development and quality of critical immunoassay reagents including managing external antibody immunization campaigns, building isotype-specific antibody reagents, purifying and characterizing proteins, conducting protein conjugations and assessing their purity and affinity. • Monitors and/or trends lot-to-lot variability, and may assist with reagent troubleshooting. • Assist in preparation of reports and documents such as characterization protocols, development reports, and testing data reports. • Assist in performing antibody titer, host cell protein ELISA, SDS-PAGE, Western blot and other Immunochemistry assays. • Other duties as assigned.

SCOPE Quantify the scope or impact of the job in terms of revenue, expenses, capital investment, headcount, etc. Research Associates play a significant role in the development and transfer of Techniques and reagents to the Quality Control group and in specialized analytical support of Process Development programs.

EDUCATION State both the minimum and the preferred educational attainment (or equivalent experience), and describe essential and desired subject matter, certifications, special training, etc.

• Bachelors or Masters degree in a physical or biological science.

EXPERIENCE State both the minimum and the preferred number of years of relevant experience, and describe the essential functions of the job. • For Research Associate 1: Bachlors degree with atleast 2 years of relevant lab experience or minimal experience with Masters. • For Research Associate 2: Bachlors degree and at least 4 years of relevant lab experience or 2 years with Masters degree. • Knowledge and experience in assay development and performance of immunoassay. • Familiarity with protein characterization would be a plus.

EQUIPMENT Describe any equipment required to perform the job. • Multi-well absorbance, electro-chemiluminescence and fluorescence plate reader and associated software. • SDS-PAGE, Western Blot, and related assay equipment. • Windows network environment, MS Office, etc. ~bio

CONTACTS We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.