• Create novel experimental designs for mechanistic toxicology studies designed to assess hypotheses for and evaluate mechanisms of toxicity related to physiological or biochemical functions
• Support predictive toxicology experimental efforts within Discovery (e.g., in vitro cell-culture based, animal models of disease) analyze safety-related data and use it to make decisions.
• As a Discovery Working Group representative, develop early safety assessment, ensure appropriate toxicology studies and liability screens are performed to support nomination of drug candidates for further development.
• Participate in issue-resolution teams, where she/he will contribute to hypotheses generation and drive the science for toxicology issue resolution in drug discovery and development.
• Communicate results clearly and concisely in both oral and written reports
• Perform in depth pathway/network analysis on data derived from toxicology and other studies and disseminate results to the wider toxicology community (internally and externally).
• Closely interact with scientists in other functional areas.
This position will require broad-based knowledge of toxicology, with emphasis on investigating molecular mechanisms of toxicity. A Ph.D. in toxicology is required, and postdoctoral experience is preferred, along with evidence of a strong publication record. This is an early career position, and at least 2 years of experience in the pharmaceutical industry is desirable, but not required. Equivalent years of experience in an academic or other laboratory setting is acceptable. The candidate should possess strong skill sets related design and implementation of investigative toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic translational toxicology studies, with a particular emphasis on comparative biology. The individual should have a creative mindset and interest in developing strategies and directing innovative approaches to measure target modulation in (normal tissues) including genetic and pharmacological validation tools. Expertise in comparative immune modulation (animals and human) and a keen interest in understanding adverse effects derived from modulation of the immune surveillance pathways and understanding regulation of innate and acquired immunity in normal tissues is desirable.