Pharmacyclics, LLC

Senior Principal Scientist, Target Discovery

Sunnyvale, CA
Jul 17, 2018
Biotech Bay
Required Education
Position Type
Full time
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in cell-signaling, immuno-oncology, and cancer stem cells with their knowledge of covalent-inhibitor, bispecific antibodies, and antibody-drug conjugates (ADCs) technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer and restore the Magic of Normal for our patients.

Pharmacyclics is seeking a broadly experienced and highly motivated Senior Principal Scientist in research biology with a proven track record of accomplishments to direct the disease biology research and new target discovery projects. This position is responsible for providing strong scientific and research team leadership to drive novel target discovery and validation research via genetic, functional genomic and pharmacological tools in the field of hematological malignancies and immune oncology. Expertise in lymphoma/leukemia biology/pathology, immunology and drug discovery is required.

Key Accountabilities/Core Job Responsibilities:

    Conceive, communicate and execute novel multi-disciplinary research strategies that encompass disease and target biology. Design and implement hypothesis-driven research proposals with a focus on specific disease mechanisms of direct therapeutic potentials in hematological malignancies and immune-oncology. Propose and validate novel therapeutic targets by combining deep understanding of mechanistic biology in hematological malignancies and immune oncology with human genetics and pathology. Design and execute in vitro, ex vivo and in vivo experiments, including functional genomic screens, to investigate disease/target biology, mechanism of action and efficacy response. Lead the development, optimization, and validation of new assays. Utilize technical expertise and available information to troubleshoot and resolve key project hurdles when encountered. Perform pharmacology experiments to analyze pharmacodynamic biomarkers and to understand the biological mechanism, disease indications and patient selection for novel targets. Effectively direct a group of discovery scientists in generating innovative technical and new target strategies that lead to the discovery of novel oncology therapeutic agents. Interact with cross-functional teams (bioinformatics, medicinal chemistry, DMPK, and pharmacology etc.) to establish productive collaborations within and outside of Pharmacyclics. Develop compelling scientific presentations and reports for internal review meetings and external scientific conferences/journals. Direct and carry out multiple scientific endeavors simultaneously, including both basic and translational research to advance research biology strategy. Lead as a role model and advance science by hand-on bench work. Actively participate in internal and external scientific meetings by presenting and critically evaluating the science and contributing to projects. Prioritize tasks and contribute to a highly motivated and productive research department with a sense of urgency and commitment to meet project timelines. Play an active role on the department leadership team, setting and implementing strategy as well as providing strong leadership and mentoring project teams and personnel.


    PhD in molecular/cell biology, cancer biology, immunology, genetics or pharmacology with >12 years industry experience in oncology target discovery/validation, small molecule drug discovery and development Broad training in cancer biology, ideally in hematological malignancies, and a deep understanding of mechanistic cancer biology, translational science and current trend in oncology therapeutics. Proven scientific leadership in mechanism of action and translational studies. Knowledge and experience in cancer genetics, cell signaling, genomics and bioinformatics are strongly required. Deep expertise and extensive experience in small molecule drug discovery and the ability to integrate in vitro and in vivo pharmacology, are necessary. Strong hands-on technical skills in lymphoma/leukemia research and/or immune oncology research. Working experience with in vitro, ex vivo and in vivo oncology disease models, functional genomic screens and bioinformatic analysis of large genomic/expression datasets. Demonstrated record of creativity and exceptional scientific achievements with strong publication and/or patent record. Broad external recognition and extensive scientific network as a thought leader in cancer biology. Experience in communicating technical information to a broad scientific audience through presentations, and written reports is essential. Proven track record in recruiting, building, managing and developing productive and effective research teams with PhD and associate scientists. Experience in successful collaborative teamwork in a matrix environment. Effective written and verbal communication skills.