Scientist, Research Biology (DMPK)

San Francisco, CA, United States
Jul 12, 2018
Biotech Bay
Required Education
Masters Degree/MBA
Position Type
Full time
Position Summary:

We are seeking a highly motivated and detail oriented scientist to join our DMPK department. The successful candidate is an experienced Bioanalytical Scientist with a strong background on LC-MS/MS. He/she will be responsible for developing quantitative LC-MS/MS methods, performing in vivo PK/PD sample analysis, and conducting in vitro ADME experiments to support Nektar's drug discovery and development programs.


The candidate will develop stage appropriate bioanalytical methods and perform in vitro/in vivo ADME and PK sample analysis. He/she will be responsible for operating and maintaining the LC-MS/MS equipment. The successful candidate must have a track record of conducting in vitro ADME experiments including but not limited to hepatocyte stability, microsomal stability, plasma/blood stability, plasma and protein binding according to defined protocols under general guidance. The candidate is expected to establish new assays as needed to advance projects. He/she will perform metabolite identification using API5500 Qtrap or Orbitrap mass spectrometer or equivalent in biological matrices from non-clinical/clinical studies. The candidate will analyze, interpret, compile, and summarize data and present conclusions to project teams and senior management. The candidate is expected to keep accurate record of experiments. He/she will write technical protocols and reports in support of regulatory filings. He/she is required to maintain compliance to company Environmental Health and Safety policies, procedures and practices.


A PhD in a scientific discipline is required. Equivalent experience may be accepted. A minimum of 2 years work experience in a research and/or development environment is required. Post-doctoral work may serve as experience. Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered. Must be an expert in scientific principles and concepts in LC-MS/MS, bioanalysis, and drug metabolism. Must be able to demonstrate success in technical proficiency, scientific creativity, collaboration with others and independent thought. Must possess good oral & written communication skills. Must be able to demonstrate sound scientific judgment. Must be able to demonstrate problem-solving capabilities. Strong organizational skills are required. Good computer skills are required. Experience with metabolite identification software, such as MetabolitePiolt™ and LightSight® is a plus. Working knowledge of MS word, Excel, Power point is a plus. Must be willing to work as part of a team. Must be able to demonstrate good interpersonal skills.

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.