Research Associate, in vivo Pharmacology
Vividion Therapeutics is seeking a highly-motivated Research Associate to contribute to the identification and development of novel small-molecule drugs. Vividion is a privately held biotechnology company based in San Diego that is leveraging an innovative and proprietary chemical proteomics platform to efficiently discover novel drugs in multiple areas including oncology and immunology.
As an early stage startup company, Vividion is looking for energetic and experienced candidates with a desire to work in a fast-paced and dynamic team environment. The successful candidate will provide in vivo support for pre-clinical drug development and discovery efforts.
Responsibilities include, but are not limited to:
- Execute pharmacokinetic / pharmacodynamic, target engagement, efficacy, or mechanism of action studies to support pre-clinical and discovery programs.
- Administer small molecule compounds to mice, measure endpoints (i.e., tumor volume, body weight) and collect blood/tissue for analysis.
- Perform in vitro cell culture and cell-based assays measuring target engagement and drug effect(s).
- Perform ex vivo assays on collected cells and tissues as needed.
- Work both independently and collaboratively as part of an in vivo pharmacology team.
- Collect, organize and present scientific/technical data internally and in project team meetings.
Experience and education requirements:
- BS with 5-7 years’ experience or MS with 3-5 years’ experience of in vivo in a biotechnology or pharmaceutical setting. Ideally the degree should be in Cancer Biology, Cancer Immunology, Pharmacology or related field.
- Rodent dosing routes (P.O., IV, IP), blood collection (sub mandibular, terminal cardiac, retro orbital), tumor implantation, necropsy, and tumor/organ collection are required.
- In vitro cell culture including culture of primary human cancer cells is required.
- Rodent surgery experience is highly desired.
- Experience with formalin fixation, paraffin embedding, sectioning, and immunohistochemistry is highly desired.
- In vivo experience focused on immuno-oncology or cancer stem cells is highly desired.
- Animal Husbandry, IACUC, and AALAC experience is highly desired.
- Effective troubleshooting and problem-solving skills.
- Excellent oral and written communication skills.
- Be an effective team player and strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines.
In addition to a competitive compensation package with stock options, Vividion also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability insurance. For consideration, please submit your resume and cover letter referencing job RAPH2018.07.10 to firstname.lastname@example.org. Vividion Therapeutics, Inc. is an EEO employer.