Sr. Associate Scientist, Immune Oncology
Other Locations:US- WA- Seattle
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global biopharmaceutical company engaged primarily in the discovery, development and commercialization of novel therapies for the treatment of cancer and inflammatory diseases through gene and protein regulation. Celgene R&D is at a critical and exciting phase of development. As it expands and integrates its portfolio, there is an opportunity for a dynamic and resourceful individual to lead our efforts in Immune Oncology at our new Therapeutic Center of Excellence in Seattle, Washington.
Reporting to Sr. Principal Scientist, Immune Oncology, the candidate will be an experienced, self-motivated, and resourceful Immunologist to join a team focused on the discovery and characterization of novel drug candidates that modulate immune system for the treatment of cancer. Candidates should have a deep understanding of cellular immunology, and/or immuno-oncology. Extensive laboratory experience with development and implementation of in vitro immunological assays for evaluating activity and mechanism of action of immuno-oncology drug candidates.
The successful candidate will be an independent contributor and work directly with corporate partners, cross-functional teams and project teams to support pre-clinical and clinical programs.
- Actively participate in the development and implementation of immune cell assays for drug candidate evaluation, mechanistic studies, and biomarker development
- Perform cell biology, molecular biology, and biochemical techniques including primary and tumor cell culture, lymphocyte activation and cytotoxicity assays, multi-parameter flow cytometry, ELISA, ELISpot, RNA preparation, RT-PCR , viral transduction, mammalian cell transfection and western blotting
- Perform a wide range of assigned research experiments with efficiency, accuracy and attention to detail, conduct analysis and report results
- Independently develop and follow protocols and function with minimal supervision
- Contribute to design of experimental procedures and search literature for targeted information.
- Interact with manager and project team to review data and plan next steps
- Record experimental details and maintain laboratory notebook
- Cultivate positive and productive working relationships with colleagues
- Prepare and present work at group meetings
- Participate in maintenance of routine laboratory instrumentation and supplies
- Use instrumentation to perform basic experiments
- Flexible to changing priorities
- Respectful of laboratory safety policies and practices
- Execute, under supervisor's direction, in-vitro immunologic assays for evaluating activity and mechanism of action of immune oncology drug candidates using key immune cell populations
- Assist in developing in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials
- Generate, analyze, and report experimental results
- Participate in Immune Oncology team meetings to present data and provide analysis
- Maintain familiarity with current techniques and procedures Maintain close effective relationships with different functional groups across the company - particularly in the molecular and cell biology arena.
- Work closely with external corporate partners to support preclinical, and translational work for immune-Oncology projects
- Contribute to the writing of non-clinical pharmacology study reports, invention disclosures, and contribute to the writing of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate
- May supervise technical staff
- Completed BS in Molecular Biology (or relevant discipline) and minimum of 14 years of pharmaceutical laboratory experience required; or
- Completed MS in Molecular Biology (or relevant discipline) and minimum of 10 years of pharmaceutical laboratory experience required; or
- Solid understanding of scientific mechanisms and experimental techniques, with knowledge of immunology and cancer cell biology preferable
- Experience in performing primary immune cell assays using key immune cell populations: CD4 and CD8 T cells, Tregs, NK cells, dendritic cells, MDSCs, and understanding immunologic pathways
- Familiarity with techniques related to biomarker research and development
- Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, Incucyte etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, microscopy), and molecular biology (expression analysis and gene silencing) techniques
- Familiarity with and experience in the drug development process from discovery through IND filing in an industry setting
- Ability to multitask, independently organize time and plan specifics of work
- Excellent communication and interpersonal skills demonstrated in a team environment
- Leadership experience in the use of innovative molecular and cellular methods to aid drug discovery efforts and a proven track record of critical contributions to drug development pipelines in immunology/immune-oncology.
- Extensive hands-on laboratory experience in developing and using state-of-the-art molecular and cell biology tools to identify and validate novel drugs candidates in primary human immune cells
- Proven track record in working in effective cross site multi-functional teams
- Team leader and team player with strong people skills. Ability to work independently but also in a collaborative manner with local and cross site teams
- Experience in working with CROs to effectively outsource research and development needs.
- Excellent communication and presentation skills.
- Strong analytical skills for integrating and interpreting interdisciplinary data
- Proven scientific track record documented by publications in high-ranking journals
- Research experience and knowledge of immune-oncology and oncology from top-level research institute or industry
- A subject matter expert with a high level of creativity
- Leader that will inspire and engage staff and colleagues across R&D
- Excellent in establishing trustful relationships, and cross-cultural understanding
- Strong, dynamic, ambitious and determined
- Creative, innovative and inquisitive personality
- Good collaboration and communication skills.
- A strong team player that brings people along through a supportive, engaged and creative way of working
The incumbent must have planning skills for scheduling experimental studies to meet project team deadlines. The position requires problem solving ability and skills in resolving technical questions in a multi-disciplinary environment. The incumbent must keep abreast of current techniques within the field and the various scientific areas affecting normal and tumor cell growth.
DIRECT and INDIRECT:
May supervises internal research associates as required.
The position is responsible for executing research plans in the defined area of investigation under direction of their supervisor. This position has responsibility for the quality, quantity, timeliness, and scientific acceptability of drug discovery activities that result in reports that are required for internal decision-making.
CONTACTS: Principal recurring contacts, including their frequency and purpose.
Moderate contact with various levels of R&D.
Limited contact with CROs and laboratories, universities and appropriate professional groups as necessary.
Domestic and international travel to scientific conferences may be required.