Principal Scientist, Cellular & Molecular Biology (Epigenetics)

San Francisco, CA
Jul 09, 2018
Required Education
Bachelors Degree
Position Type
Full time

Other Locations:US- CA- San Francisco- Owens Street Celgene

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Translational Development (TD) at Celgene

The role of TD at Celgene is to bridge discovery with late-stage clinical development.  Our translational scientists generate and evaluate clinical and preclinical data to help guide clinical development.  We are organized into biology thematic areas that share joint responsibility for discovery and early development.  Within these teams, TD provides leadership for early clinical programs from candidate nomination to trials designed to achieve clinical proof of concept and set the foundation for pivotal (registration) studies.  The TD group is also responsible for working with Discovery to develop target validation approaches, define appropriate disease models, and catalyze early engagement between Discovery and Early Development teams to define biomarkers and patient selection strategies, and with Clinical Pharmacology to define starting doses and schedules for dose escalation in Phase 1 studies. Rational combinations of novel molecules is also a focus.

Responsibilities will include, but are not limited to, the following:

Design and execute experiments, using internal or external resources as appropriate, to define and test hypotheses for selection of tumor type, patient subgroups, or drug combinations for small molecules and biologics.  Develop and/or characterize pre-clinical and clinical methods for measuring pharmacodynamic (PD) effects and surrogate markers for efficacy to guide determination of dose, schedule, and priority indications in clinical trials.  Design and execute biomarker and correlative components of clinical trials, including participation on trial teams, management of vendors, analysis of data, and communication with study investigators and other stakeholders.  Independently identify and manage collaborative relationships with academic investigators, for both clinical trials and preclinical studies.  Provide strategic and disease biology leadership to set science-driven, patient-focused priorities for development of Celgene's pipeline.   

Skills/Knowledge Required:

  • Advanced knowledge of oncology, including disease biology, treatment approaches, agents in development, and competitive landscape.   

  • Expertise in molecular and cellular biology, covering concepts and experimental methods, such as cell culture, cell-based assays, FACS, ELISAs, Western blots, gene expression, si/shRNA/CRISPR, analyses of splice variants, and/or ex vivo immune cell assays

  • Exceptional interpersonal and communication skills

  • Ability to independently represent the science in interactions with clinicians and thought leaders across multiple areas of oncology; ability to present to high-level audiences. 



Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.