Pharmacology Associate II
Adverum Biotechnologies is a gene therapy company committed to discovering and developing novel therapeutics that can offer life-changing benefits to patients living with rare diseases or diseases of the eye who currently have limited or burdensome treatment options. With competent skills in laboratory animal science, work closely with the members of Preclinical Development to evaluate therapeutic candidates in animal models. The ideal candidate will possess a minimum of 3-5 years experience executing Preclinical in vivo studies. The candidate must demonstrate proficiency in all commonly utilized rodent biomethods. Working knowledge of laboratory animal health and welfare, as well as an understanding of Preclinical drug development processes, are essential. Must be willing to travel between Adverum’s office in Menlo Park, CA and the offsite Vivarium, located in Mountain View, CA. The position will report directly to the Sr Preclinical Study Coordinator.
• Motivated self-starter that functions efficiently when working both independently, and in a small group setting.
• Experience with animal model development, preferably ocular disease models
• Perform administrations via IP, IM, SC, IV, intravitreal and subretinal routes
• Perform blood collection via submandibular, retro-orbital, and cardiocentesis routes
• Perform necropsy and tissue collection for Non-GLP preclinical studies
• Experience establishing, and maintaining, study sample inventories in a cross-functional team setting
• Experience establishing, and maintaining, a laboratory supply inventory system; setting up vendor accounts, placing and receiving orders, tracking usage and anticipating supply needs
• Ability to adapt in a fast-paced environment and remain flexible to shifting priorities
• Proficiency in Microsoft Word, Excel, PowerPoint and GraphPad Prism
• Above average organizational skills and attention to detail
• Experience with planning and executing Preclinical in vivo studies. Ability to assist with the write-up of study protocols and reports
• Understanding of program timelines, with emphasis on specific deliverables
• Working knowledge of Gene Therapy, specifically AAV Vectors
• Experience with ocular disease models; performing regular ocular examinations and imaging utilizing slit lamp, fundus microscope, optical coherence tomography (OCT), and electroretinography (ERG) ophthalmic equipment.
• Experience conducting tissue isolation, fixation, preparation of tissue sections, tissue staining including immunohistochemistry and ELISA-based assays