Senior Scientist - Pharmacokinetics & Drug Metabolism

Cambridge, Massachusetts
Jun 27, 2018
Required Education
Position Type
Full time

Amgen is seeking a Neuroscience focused Senior Scientist to join the Pharmacokinetics and Drug Metabolism (PKDM) department at our Kendall Square site in Cambridge, Massachusetts.

In this role you will provide expertise in the pharmacokinetic and drug metabolism aspects of neuroscience drug discovery and development. With proven expertise in this area you will contribute to Amgen's diverse discovery and development portfolio of therapeutic modalities including small molecules, protein biotherapeutics and other innovative strategies. You will work directly with other PKDM stakeholders at multiple Amgen research sites (Cambridge, MA, San Francisco and Thousand Oaks, CA) to influence drug discovery direction including interpretation and communication of the impact of ADME/PK/PD data on drug efficacy, safety, chemistry, protein science strategy, and clinical pharmacology planning to advance the best therapeutic candidates. In addition, this position will make meaningful and innovative contributions to the fundamental understanding of the biological factors that affect the distribution, metabolism and clearance of multiple modalities with a focus on neuroscience program support.

In this position the core responsibilities are to:

- Guide strategy and provide subject matter expertise for the ADME sciences with a focus on neuroscience programs within the PKDM organization in Cambridge

- Plan, design, and conduct fit for purpose in vitro and in vivo studies; analyze, interpret, integrate and communicate study results

- Devise, articulate, and implement strategies for improvement of blood brain and blood nerve barrier distribution as well as the clearance and safety properties for candidate molecules

- Lead the implementation of new technologies, improved processes and evaluation of new chemical and biological entities aimed at improving therapeutic options towards neuroscience drug targets

In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the distribution and metabolism of small and large molecule biotherapeutics including mechanistic studies. The role requires skills consistent with effective PKDM project team representation. A collaborative and highly capable scientific cross-site community at Amgen is available to support these efforts.

Basic Qualifications:

Doctorate degree & 2 years of Scientific experience


Master's degree & 5 years of Scientific experience


Bachelor's degree & 7 years of Scientific experience

Preferred Qualifications:

Ph.D. in a biology, pharmaceutical science, chemistry or equivalent field of study

3 years of drug discovery and development experience including contribution to regulatory filings

Expertise with strategies and technologies to guide chemistry and/or protein sciences towards blood brain barrier penetrating molecules

Expertise in interpretation of PK/PD/ADME data and translation to impact on program direction (e.g. influencing molecule design cycle)

Critical thinking and demonstrated ability to communicate with team members across broad disciplines

Effective oral and written communication skills