Head of Protein Sciences

94080, South San Francisco
Jun 20, 2018
NextGen Bio
Required Education
Position Type
Full time

Head of Protein Sciences

Surrozen is seeking an experienced Protein Scientist with expert knowledge in expression, purification and characterization of antibody-based therapeutics.  The ideal candidate will be an energetic self-starter, adept at working in a fast-paced, nimble startup and equally skilled working collaboratively.



  • Purification and characterization of diverse biologics, including bispecific and engineered antibodies for early-stage screening and preclinical research work
  • Process development for complex antibodies and bispecific production to enable protocol transfer to contract manufacturing organizations
  • Characterization of purified material using mass spectrometry, light scattering, IEF, HPLC and other biophysical techniques to generate data package for lead finding, optimization, and developability assessment
  • Lead antibody production efforts on project teams and collaborate with protein engineering, molecular assessment, and CMC groups to advance therapeutic programs to clinical development
  • Assess, select and manage CMO’s for clinical and commercial stage antibody production


  • PhD. in Biochemistry, Biology, or related field with 5+ years or BS/MS with 10+ years of industry experience
  • Extensive experience in protein purification and characterization, including bi- and multi-specific antibody purification
  • Ability to develop various HPLC based assays. Familiarity with AKTA, LC-MS, SEC-MALS, HPLC, and HIC
  • Ability to work independently in a highly dynamic and fast-paced environment to contribute to multiple projects
  • A self-motivated individual with excellent record keeping and written and verbal communication skills
  • CRO management experience
  • CMO management experience


  • Knowledge of formulation of antibody-based therapeutics
  • Familiarity with protein structure-function relationships
  • Familiarity with screening of multiple-format antibody libraries against cell-surface targets