Head of Protein Sciences

Location
94080, South San Francisco
Posted
Jun 20, 2018
Hotbed
NextGen Bio
Required Education
Doctorate/PHD/MD
Position Type
Full time

Head of Protein Sciences

Surrozen is seeking an experienced Protein Scientist with expert knowledge in expression, purification and characterization of antibody-based therapeutics.  The ideal candidate will be an energetic self-starter, adept at working in a fast-paced, nimble startup and equally skilled working collaboratively.

 

Responsibilities:

  • Purification and characterization of diverse biologics, including bispecific and engineered antibodies for early-stage screening and preclinical research work
  • Process development for complex antibodies and bispecific production to enable protocol transfer to contract manufacturing organizations
  • Characterization of purified material using mass spectrometry, light scattering, IEF, HPLC and other biophysical techniques to generate data package for lead finding, optimization, and developability assessment
  • Lead antibody production efforts on project teams and collaborate with protein engineering, molecular assessment, and CMC groups to advance therapeutic programs to clinical development
  • Assess, select and manage CMO’s for clinical and commercial stage antibody production

Requirements:

  • PhD. in Biochemistry, Biology, or related field with 5+ years or BS/MS with 10+ years of industry experience
  • Extensive experience in protein purification and characterization, including bi- and multi-specific antibody purification
  • Ability to develop various HPLC based assays. Familiarity with AKTA, LC-MS, SEC-MALS, HPLC, and HIC
  • Ability to work independently in a highly dynamic and fast-paced environment to contribute to multiple projects
  • A self-motivated individual with excellent record keeping and written and verbal communication skills
  • CRO management experience
  • CMO management experience

Desirable:

  • Knowledge of formulation of antibody-based therapeutics
  • Familiarity with protein structure-function relationships
  • Familiarity with screening of multiple-format antibody libraries against cell-surface targets